GI / Nutrition Flashcards
MC mechanism for GERD ; RF
Transient LES relaxation
RF =
ETOH, caffeine , obesity, smoking , hiatal hernia
When does heartburn occur in GERD
30-60 mins after meals
Alarm features of GERD [4]
Refractory Heartburn
Dysphagia
Unintentional weight loss
GI Bleed/IDA
Refractory GERD with negative endoscopy = get what test
Amb pH monitoring ; acidity confirming test
Peristaltic abnormalities / or pre op before GERD surgery get what?
Manometry ; dysphagia ID
Mild treatment GERD
Lifestyle
Tums
H2 blockers
Persisitant sxs GERD think what TXM
PPI once daily for 4-8 weeks
Reflux esophagitis is what two etiologies
Mechanical or Functional
Dx for Reflux esophagitsi
Endoscopy w/ biopsy
TXM for reflux esophagitis
PPI x2 daily [4-8 weeks]
Barrets makes you at risk for what
Adenocarcinoma ; metaplastic columnar epithelium change
Salmon colored mucosa makes you think what
Barrett’s
Barrets get PPI when ; survelience?
For life x2 daily
EGD every 3-5 years
Infectious esophagitis effects who most
HIV DM Chemo therapy patients
Infectious esophagitis 3 diff types and what they look like ; TXM
CMV = large ulcers ; linear [TXM = IV ganciclovir/foscarnet]
HSV : multi small ulcers less 2cm [TXM = PO acyclovir]
Candidi = white plaques [TXM = PO fluconazole]
How long can pill induced esophagitis last
Hours to days after ingestion
Pill induced esophagitis study of choice
Initial double contrast esophagram
Def = upper endoscopy
Radiation esophagitis can cause what
Impaired peristalsis decreased motility due to edema inflammation
Treatment for trouble swallowing
Prokinetics
E o E usually of hx of what
Allergies or atropy as a child
E o E looks like what on endoscopy
White exudates ; red furrows ; concentric rings
Bx= + eosinophilia
E o E txm?
Budesonide or fluticasone
Swallow instead of inhaling
Peristalsis and LES tone in achalasia
Peristalsis is decreased ; LES in increased
Dx of choice most sensitive for achalasia
Dx = barium swallow
Most sensitive = manometry
CREST with Scleroderma
Caclicnosis
Raynauds
Esoph dysmotitlity = solids and liquids
Scledorodactyly
Telangiectasia
Barium vs manometry on esophageal spasms
Corkscrew = Barium swallow
Nutcracker = manometry
MI pain with dysphagia
Zenkers outpouch where?
Posterior hypopharnyx
Dysphagia coughing regurgitation halitosis
Zenkers
when do surgically treat Zenkers
If dysmotility is severe
SCC risk factors in the throat
Tobacco and ETOH
Peptic stricture is a complication of what 2 things
GERD and Esophagitis
Peptic stricture is usually more of a problem of swallowing
Solids
Esophageal webs vs schatzkis rings
EW = proximal ; solids > liquids ; barium = shelf
Schatzkis = distal ; heartburn solids > liquids ; barium = esophageal narrowing
TXM = dilation and PPI for heartburn
Plummer Vinson syndrome [4]
Cervical esophageal webs
IDA
Stomatitis
Glossitis
Solid and liquid dysphagia =
Motility disorder
Dysphagia to liquids think what
Neurogenic cause
Low grade esoph varices presentation
Melena + IDA
Pharm therapy for esophageal varices
Vit K = abnormal PT
Laculose = encephalopathy
ABX prob = IV FQ or Cef
MW tear occurs where
GE junction
Self limiting hematemesis
Heavy ETOH after forced RETCHING
Most MW tears heal when
48 hours with PPI txm
Refractory = epinephrine or coagulation
Gastritis 4 etiologies
NSAIDS
ETOH
Stress
Portal HTN
What med can coat the stomach and treat pain in gastritis
Sucralfate
AIG = auto immune gastritis
Pernicious enemies
Dec IF secretion —> B12 def. —> anemia.
TXM = B12 r2 and survellience endoscopy
H. Pylori risk factor ;; looks like?
Travel and eating different foods
Gram negative spiral shaped bacillus
Dx of H. Pylori
Urea breathe test
TXM H. Pylori
14 days of Quad Therapy : PBMT
PPI + Bismuth + Tetracycline + Metronidazole
CLARITHRO less 15% = triple therapy
PPI + amoxicillin + CLARITHROMYCIN
3 complication of H Pylori
Gastric cancer
MALT Lymphome
PUDz
NSAID // H pylori cause what ulcers
NSAIDS = gastric
H pylori = duodenal
PUD dz
Upper endoscopy bx ro r/o H pylori and malignancy
Treatment gastric ulcer vs. duodenal
Gastric = PPI x 8 weeks
Duodenal = PPI x 4 weeks
Gastric neos = MC
Adenocarcinoma
[Virchow node// Sister Mary Joseph nodule // krukenberg tumor]
Gastric Lymphoma MC in
Non Hodkin B cell lymphoma
ZES is what kind of tumor
NE tumor gastric secretin = increased acid production
[MEN-1 Syndrome]
Hella Refractory Ulcers
Gastrin can cause what kind of diarrhea
Secretory = normal stool ion gap ; high purge rate ; no response to fasting
ZES for gastrin level over
150
PH less 2.0
Pyloric stenosis Mc cause of what
Gastric outlet obstruction in infants
Succession splash think what
PS
MC gallstones are what
Cholesterol
Think the F’s
What two things can prevent gallstones
ASA and NSAIDS
Abdominal pain after fatty meal colicky RUQ pain
Cholelithiasis
Cholecystitis impacted gallstone where
Cystic duct
What chole sign inhibits inspiration
Murphys
Most definitive test of cholecystitis
HIDA scan
TXM cholecystitis
IV fluids
Bowel Rest
IV ABX : Metro and CIPRO
Pain management
4 complications of cholecystectomy
CBD stone
Bile duct stricture
Bile acid induced diarrhea
Sphincter of oddi dysfunction
Chronic Cholecystitis
Repeat irritation
RUQ pain vague dull does not go away
Nausea
Fatty meals make it worse ; but does go away
CBD stones RF
Stones
Biliary stairs s
S/p cholecystectomy
Large glass tone in the duodenum causing SBO think what
Gallstones ILEUS
Gold standard for CBD stone
ERCP
Cholangitis MC organisms
E Coli
Klebsiella
Enterococcus
Enterobacter
Charcots Cholangitis
RUQ Fever Jaundice
PENTAD = AMS + Hypotension
What do you give after ERCP to prevent post ERCP pancreatitis
Indomethacin
cholangitis ABX of choice
Piperzillan / Taxobactam
What type of Hep is common in endemic areas
AE
What type of hep is blood borne
BC
Aversion to smoking occurs think what
Hepatitis
What type of hep is fecal to oral
Hep. A
What type of Hep do we have PEP meds ?
A and B
Acute hepatitis
IgM
Previous hepatitis infection
IgG
Vaccination are usually [hepatitis]
Anti HAVE IgG
Anti -HBs
Hep B previos infection think positive what
Core antigen
Hep A B C treatment
A = self limited
B = antivirals [tecavir]
C = monitor for 3 months ; protease inhibitor [simeprevir] NS5B ;
Needles stick HEp C exposure mangement
RNA/LFTs @ 2 wk ; 4 wk ; 6 months
Heb B vaccine is when
0 , 1, 6 months
What type of hep has vaccines
A and B
MC of ALF in the US
APAP toxicity and drug rxns
N acetycystein only given in APA if when
Less than 72 hours
Chronic viral hepatitis worry about
Progression to cirrhosis or carcinoma of liver
Alcoholic Hepatitis think what LFTS
AST > ALT
GGT+
elevated ALK phos and Bilirubin
PROLONGED PT
3 nutritional deficiencies in alcoholic hepatitis
Thiamine
Folic Acid
Zinc
Improves circulation prevents hepatorenal syndrome ; treatment in alcoholic hepatitis ?
Pentoxyfilline
Reduces short term mortality in alcoholic hepatitis
Methlyprednisolone
Infection complications common in alcoholic hepatitis
Aspergillosis - fungal infection