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Gastro Review > GI motility@ > Flashcards

GI motility@ Flashcards

1
Q

Which nerves responsible for lower colon excitatory fxn?

A

Sacral plexus or sacral parasymp nerves (S1-5)

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2
Q

Which nerve has great effect on eosph/stom?

A

Vagus via cranial parasymp nerves

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3
Q

T/F: Food is a stimulator of the MMC?

A

False, it is an inhibitor; the MMC empties non food materials

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4
Q

When does GB and panc emptying happen in the MMC?

A

I - Quiescent phase

II & III - GB empty, panc/biliary emptying

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5
Q

Gastric electrical stim works how?

A

Improved accomodation, improved vagal fcn, dec sensitivity to distention, inc slow wave amplitude

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6
Q

T/F: Gastric elec stim works best in diabetics.

A

True

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7
Q

Skeletal bx with ragged red fibers in what?

A

mitochondrial neurogastrointestinal encephalomyopathy

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8
Q

T/F: MNGIE has atrophy and fibrosis of longitudinal muscle of MP?

A

True

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9
Q

What genetic defect and inheritance of MNGIE?

A

AR, defect in thymidine phosphorylase

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10
Q

CIs to use of neostigmine?

A

Bradycardia

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11
Q

List the 3 muscles of the UES.

A

Inf pharyngeal constrictor, cricopharyngeus, cervical esophagus

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12
Q

Achalasia is a RF for which type of esophageal CA?

A

SCC

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13
Q

Which dzes can cause low LES resting pressure?

A

DM, scleroderma, thyroid dz

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14
Q

Which reflex is abnl in Hirschsprungs?

A

Rectoanal inhibitory reflex

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15
Q

Hirschsprungs AW which dz?

A

Downs syndrome

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16
Q

CIPO tx?

A

octreotide before bedtime; can worsen if done before meals

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17
Q

SCLC paraneoplastic syndrome AB?

A

Anti-Hu or Anti-neuronal nuclear AB

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18
Q

Which nerves give excitatory control of distal colon?

A

Sacral plexus nerves

19
Q

What gives motor control to UES?

A

Cranial parasympathetic outflow mediated by vagus nerve

20
Q

What mediates OP swallowing?

A

Swallowing center in medulla

21
Q

Tx of high up Zenkers?

A

Cricopharyngeal myotomy with diverticulectomy

22
Q

WHat is responsible for moving nondigestible products through the stomach?

A

MMC

23
Q

Phase(s) of solid food gastric emptying

A

Lag and linear phases

24
Q

T/F: Higher caloric density foods have faster gastric emptying.

A

False, empty slower

25
Q

What is the MMC?

A

Phase of emptying of the stomach and SI that occurs between meals.

26
Q

Does food stim or inhibit MMC?

A

Inhibits it

27
Q

What are three phases of MMC?

A
  1. Quiescent

2&3. Active stages

28
Q

How does fat in the ileum affect gastric emptying?

A

Fat in the ileum leads to GLP1 release which delays gastric emptying

29
Q

What is the best gastroparesis diet?

A

Low fat, low fiber

30
Q

What is the SE of domperidone?

A

breast discharge

31
Q

What is the mechanism of improvement with gastric pacemaker?

A

Improvement in gastric accomodation

32
Q

What tx of scleroderma induced SIBO can be helpful?

A

Low dose night time octreotide by inducing MMC overnight

33
Q

What would rectal exam show if internal anal sphincter problem in scleroderma? What would happen on balloon expulsion?

A

Weak resting sphincter tone, normal balloon expulsion time

34
Q

Achalasia is too much of what neurotransmitter?

A

ACh

35
Q

Which type of achalasia responds best to dilations?

A

Type 2

36
Q

Besides achalasia type, which other factors predict good response to dilations?

A

Age > 45, females, smaller initial diameter

37
Q

Name the 3 types of achalasia

A

Type 1 - absent peristalsis
Type 2 - pan eosphageal pressurization
Type 3 - SPastic achalasia

38
Q

What is the best predictor of response in achalasia?

A

Post dilation LES pressure < 10 mmHg

39
Q

T/F: Hot meals have higher gastric empyting than cold meals.

A

False, temp does not make a difference

40
Q

What NTs are responsible for ileal brake?

A

Peptide YY & GLP1

41
Q

Best tx of CIPO?

A

Night time octreotide

42
Q

Which 2 ABs MC seen in paraneoplastic syndromes?

A

Anti-Hu AB and anti-neuronal nuclear AB

43
Q

How does neostigmine work?

A

AChE inhibitor

44
Q

Which conditions put pt at higher risk when getting neostigmine?

A

Cardiac arrhythmias, asthma, bradycardia, seizures, myasthenia gravis

Gastro Review (15 decks)

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