GI Medications Flashcards
Misoprostol (Cytotec)
Gastric Protectant
Suppresses gastric acid secretion, prevents ulcers from NSAIDs
Sucralfate (Carafate)
Gastric Protectant
Creates protective barrier from acid and pepsin
*Give on empty stomach
Pirenzepine (Gastrozepine)
Muscarinic Antagonist. Suppresses gastric acid secretion
Histamine 2 (H2)-Receptor Antagonists
Suppresses gastric acid secretion
- Alleviates symptoms of heartburn - Prevents stress ulcers - Promotes healing in GERD
Cimetidine (Tagamet)
Histamine 2 (H2)-Receptor Antagonists
Suppresses gastric acid secretion
- Alleviates symptoms of heartburn - Prevents stress ulcers - Promotes healing in GERD
Side effects: Confusion
Ranitidine (Zantac)
Histamine 2 (H2)-Receptor Antagonists
Suppresses gastric acid secretion
- Alleviates symptoms of heartburn - Prevents stress ulcers - Promotes healing in GERD
Famotidine (Pepcid)
Histamine 2 (H2)-Receptor Antagonists
Suppresses gastric acid secretion
- Alleviates symptoms of heartburn - Prevents stress ulcers - Promotes healing in GERD
Nizatidine (Axid)
Histamine 2 (H2)-Receptor Antagonists
Suppresses gastric acid secretion
- Alleviates symptoms of heartburn - Prevents stress ulcers - Promotes healing in GERD
Proton Pump Inhibitors
Suppress gastric acid secretion
-Treats active ulcer disease, erosive esophagitis
Esomeprazole (Nexium)
Proton Pump Inhibitor
Suppress gastric acid secretion
-Treats active ulcer disease, erosive esophagitis
Lansoprazole (Prevacid)
Proton Pump Inhibitor
Suppress gastric acid secretion
-Treats active ulcer disease, erosive esophagitis
Omeprazole (Prilosec)
Proton Pump Inhibitor
Suppress gastric acid secretion
-Treats active ulcer disease, erosive esophagitis
Pantoprazole (Protonix)
Proton Pump Inhibitor
Suppress gastric acid secretion
-Treats active ulcer disease, erosive esophagitis
Raberprazole (Aciphex)
Proton Pump Inhibitor
Suppress gastric acid secretion
-Treats active ulcer disease, erosive esophagitis
Medication Regimen for Treating H. pylori infections
Antibiotics and PPI. Purpose is to protect the ulcer and kill the bacteria.
Triple Therapy
-Esomeprazole (Nexium), Amoxicillin (Amoxil), Clarithromycin (Biaxin)
or
Quadruple Therapies
- Esomeprazole (Nexium), Metronidazole (Flagyl), tetracycline, bismuth subsalicylate - Ranitidine (Zantac), Metronidazole (Flagyl), tetracycline, bismuth subsalicylate
Metoclopramide (Reglan)
Prokinetic Agent. Increases gastric emptying. Used to treat gastric reflux, vomiting, and paralytic ileus.
*Contraindicated in obstruction, hemorrhage, or perforation
Bile Acid Sequestrants
Helps rid body of bile salts through the feces.
-Treats hypercholesterolemia, biliary obstruction, pruritus associated with biliary disease
*Note: Can worsen suspected bowel obstruction or severe constipation
Colesevelam (Welchol)
Bile Acid Sequestrant
Helps rid body of bile salts through the feces.
-Treats hypercholesterolemia, biliary obstruction, pruritus associated with biliary disease
*Note: Can worsen suspected bowel obstruction or severe constipation
Cholestryamine (Questran, Prevalite)
Bile Acid Sequestrant
Helps rid body of bile salts through the feces.
-Treats hypercholesterolemia, biliary obstruction, pruritus associated with biliary disease
*Note: Can worsen suspected bowel obstruction or severe constipation
Colestipol (Colestid)
Bile Acid Sequestrant
Helps rid body of bile salts through the feces.
-Treats hypercholesterolemia, biliary obstruction, pruritus associated with biliary disease
*Note: Can worsen suspected bowel obstruction or severe constipation
Lactulose (Constulose, Enulose)
Treats hepatic encephalopathy by increasing peristalsis to expel ammonia in stool.
Pancreatic Enzyme Replacements
Increases pancreatic enzymes to improve nutritional status and reduce the amount of fatty stools.
Pancreatin
Pancreatic Enzyme Replacement
Increases pancreatic enzymes to improve nutritional status and reduce the amount of fatty stools.
Pancrelipase IPancrease MT, Viokase, Lipram, Pancrecarb MS)
Pancreatic Enzyme Replacement
Increases pancreatic enzymes to improve nutritional status and reduce the amount of fatty stools.
Medications to treat Inflammatory Bowel Disease (Crohn’s Disease and Ulcerative Colitis)
- ) Antimicrobials - Prevent infections
- ) 5-Aminosalicylates - Decrease gastrointestinal inflammation
- ) Corticosteroids - Anti-inflammatory
- ) Immunosupressants
- ) Immunomodulators - Induce and maintain remission
Alosetron (Lotronex)
Treats severe irritable bowel syndrome (IBS)
Lubiprostone (Amitiza)
Treats irritable bowel syndrome (IBS) by increasing intestinal motility and passage of stools to reduce abdominal pain
Tegaserod (Zelnorm)
Treats irritable bowel syndrome (IBS) by decreasing visceral sensation and increasing GI motility and secretions
Antiemetics
Used to control vomiting and motion sickness
*May cause drowsiness, protect from injury
Bulk-forming laxatives
Absorb water into feces and increase bulk to produce large, soft stools
- Contraindicated in bowel obstruction
- May cause dehydration
Methylcellulose (Citrucel)
Bulk-forming laxative
Absorb water into feces and increase bulk to produce large, soft stools
- Contraindicated in bowel obstruction
- May cause dehydration
Polycarbophil (FiberCon)
Bulk-forming laxative
Absorb water into feces and increase bulk to produce large, soft stools
- Contraindicated in bowel obstruction
- May cause dehydration
Psyllium (Metamucil)
Bulk-forming laxative
Absorb water into feces and increase bulk to produce large, soft stools
- Contraindicated in bowel obstruction
- May cause dehydration
Stimulant Laxatives
Stimulate motility of large intestine
Bisacodyl (Correctol, Dulcolax, Feen-a-mint, Fleet laxative)
Stimulant Laxative
Stimulate motility of large intestine
Senna (Senokot Ex-Lax)
Stimulant Laxative
Stimulate motility of large intestine
Surfactant Laxatives
Inhibit absorption of water so fecal mass remains large and soft. Used to avoid straining
Ducosate sodium
Surfactant Laxative
Inhibit absorption of water so fecal mass remains large and soft. Used to avoid straining
Osmotic Laxatives
Attract water into large intestine to produce bulk and stimulate peristalsis
Magnesium hydroxide (Milk of Magnesia)
Osmotic laxative
Attract water into large intestine to produce bulk and stimulate peristalsis
Magnesium citrate (Citrate of Magnesia)
Osmotic laxative
Attract water into large intestine to produce bulk and stimulate peristalsis
Sodium phosphates (Fleet enema, Fleet Phospho-Soda)
Osmotic laxative
Attract water into large intestine to produce bulk and stimulate peristalsis
Polyethylene glycol and electrolytes (GoLYTELY)
Osmotic laxative
Attract water into large intestine to produce bulk and stimulate peristalsis
Lubricant Laxatives
Soften the feces, ease the strain of passing stool, and lessen irritation to hemorrhoids
Mineral Oil
Lubricant laxative
Soften the feces, ease the strain of passing stool, and lessen irritation to hemorrhoids