GI Drug Actions

Question 1

Muscarinic RA example

Answer 1

hycosine hydrobromide

Question 2

Muscarinic RA MOA

Answer 2

competitive X M ACh Ys in vestibular nuc

- CTZ

Question 3

MRA side effects

Answer 3

sedation 
memory problems
glaucoma
dry mouth
constipation

Question 4

H1 RA examples

Answer 4

cyclizine

promethazine

Question 5

H1 RA MOA

Answer 5

x Histaminergic signals from vestibular system > CTZ (medulla)

Question 6

H1 RA indications

Answer 6

pregnancy

motion sickness

Question 7

H1 RA contraindications

Answer 7

little old ladies

children

Question 8

H1 RA side effects

Answer 8

dry mouth 
constipation 
UR 
sedation / excitation 
cardiac toxicity

Question 9

5HT3 examples

Answer 9

ondansetron

Question 10

5HT3 MOA

Answer 10

v GI motility
v GI secretions
- CTZ

Question 11

5HT3 side effects

Answer 11

(uncommon) 
constipation 
headache
^ liver enzymes
long QT  
EP effects

Question 12

D2 RA examples

Answer 12

domperidone

metoclopramide

Question 13

D2 RA MOA

Answer 13

^ ACh at M Ys in visceral system

> ^ gastic emptying / ^ peristalsis

Question 14

D2 RA indications

Answer 14

GORD
ileus
breast feeding mothers

Question 15

D2 RA side effects

Answer 15

galactorrhoea
EP side effects
cardiac death (domperidone)

Question 16

NK1 RA examples

Answer 16

aprepitant
fosaprepitant
netupitant

Question 17

NK1 RA MOA

Answer 17

x Substance P @ CTZ

^ 5HT3 RA effect

Question 18

NK1 RA indications

Answer 18

chemotherapy

Question 19

NK1 RA side effects

Answer 19

headache
diarrhoea
SJS

Question 20

opioid receptor agonist example

Answer 20

loperamide
codeine
morphine

Question 21

opioid receptor agonist indications

Answer 21

diarrhoea

pain

Question 22

opioid receptor agonist effect

Answer 22

v SM tone
v peristalsis BUT ^ segmental contractions
v colonic mass movement

Question 23

opioid receptor agonist side effects

Answer 23

paralytic ileus
nausea 
vomiting
sedation 
addiction

Question 24

osmotic laxative example

Answer 24

lactulose
movicol
cosmocol

Question 25

stimulant laxatives examples

Answer 25

docusate sodium

Question 26

bulk forming laxative examples

Answer 26

ispaghula hisk

methycellulose

Question 27

stool softeners example

Answer 27

decussate sodium
gycerine
liquid paraffin