GI Drug Actions Flashcards
Muscarinic RA example
hycosine hydrobromide
Muscarinic RA MOA
competitive X M ACh Ys in vestibular nuc
- CTZ
MRA side effects
sedation memory problems glaucoma dry mouth constipation
H1 RA examples
cyclizine
promethazine
H1 RA MOA
x Histaminergic signals from vestibular system > CTZ (medulla)
H1 RA indications
pregnancy
motion sickness
H1 RA contraindications
little old ladies
children
H1 RA side effects
dry mouth constipation UR sedation / excitation cardiac toxicity
5HT3 examples
ondansetron
5HT3 MOA
v GI motility
v GI secretions
- CTZ
5HT3 side effects
(uncommon) constipation headache ^ liver enzymes long QT EP effects
D2 RA examples
domperidone
metoclopramide
D2 RA MOA
^ ACh at M Ys in visceral system
> ^ gastic emptying / ^ peristalsis
D2 RA indications
GORD
ileus
breast feeding mothers
D2 RA side effects
galactorrhoea
EP side effects
cardiac death (domperidone)
NK1 RA examples
aprepitant
fosaprepitant
netupitant
NK1 RA MOA
x Substance P @ CTZ
^ 5HT3 RA effect
NK1 RA indications
chemotherapy
NK1 RA side effects
headache
diarrhoea
SJS
opioid receptor agonist example
loperamide
codeine
morphine
opioid receptor agonist indications
diarrhoea
pain
opioid receptor agonist effect
v SM tone
v peristalsis BUT ^ segmental contractions
v colonic mass movement
opioid receptor agonist side effects
paralytic ileus nausea vomiting sedation addiction
osmotic laxative example
lactulose
movicol
cosmocol
stimulant laxatives examples
docusate sodium
bulk forming laxative examples
ispaghula hisk
methycellulose
stool softeners example
decussate sodium
gycerine
liquid paraffin
