GI Flashcards by Alexandra Holley

Q

Omeprazole

A

PPI

> parietal cell canaliculus (HKATPase)

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Q

Cimetidine

A

H2RA
H2R: parietal cell
v cAMP > v => H+
(+ PKA, - gastrin / ACh

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Q

Amoxicillin

A

H pylori ABX

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Q

Calcium carbonate

A

Antacid

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Q

Aluminium hydroxide

A

Antacid

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Q

Clarithromycin

A

H pylori ABX

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Q

Magnesium hydroxide

A

Antacid

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Q

Sodium hydroxide

A

Antacid

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Q

Misoprostol

A

Prostaglandin analogue

Parietal PGE2

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Q

Codeine

A

Opioid receptor antagonist

U/D receptors: myenteric plexus

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Q

Movicol

A

Osmotic laxative
LB
(= macrogols)

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Q

Glycerin

A

Stimulant laxative

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Q

Docusate sodium

A

Stimulant laxative

Gut

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Q

Lactulose

A

Osmotic Laxative

LB

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Q

Morphine

A

Opioid receptor antagonist

U/D receptors of myenteric plexus

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Q

Loperamide

A

Opioid receptor antagonist

U receptors in myenteric plexus

Q

Ispaghula husk

A

Bulk forming laxative

Q

Methyl cellulose

A

Bulk forming laxative

Q

Aprepitant

A

Neurokinin 1 receptor antagonist

5HT3 receptor, CTZ

Q

Hyoscine hydrobromide

A

M receptor antagonist

Vestibular nuclei

Q

Fosaprepitant

A

NK1 receptor antagonist

Q

Netupitant

A

NK1 RA

5HT3, CTZ

Q

Cyclizine

A

H1 Receptor antagonist

Vestibular nuclei

Q

Ondasteron

A

5HT3RA

visceral afferents

Promethazine

H1RA | Vestibular nuclei

Cinnirazine

H1RA | vestibular nuclei

Prochlorperazine

D2RA | Visceral afferents

Metoclopramide

D2RA | Visceral afferents

Domperidone

D2RA | visceral afferents

Haloperidol

D2RA | Visceral afferents

Dexamethasone

Corticosteroids | CTZ / D2R

Nabilone

Cannabinoids | CTZ

Methylprednisolone

Corticosteroids | CTZ / D2R

Benzodiazepine

GABA receptor antagonist | CTZ / 5HT3

Mirtazepine

5HT3 (TCA)

Gabapentin

GABA mimic | ^5HT3

Cisapride

Prokinetic | LOS / Pylorus

Midazolam

``` CTZ / 5HT3 GABA receptors (v => 5HT3) ```