GI Cancer Flashcards

1
Q

What staging system is used for colorectal cancer?

A

Duke’s Stages

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2
Q

What is Duke Stage A?

A

Tumour confined to submucosa

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3
Q

What is Duke Stage B1?

A

Growth into muscularis propria

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4
Q

What is Duke Stage B2?

A

Growth through muscularis propria and serosa (full thickness)

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5
Q

What is Duke Stage C1?

A

Spread to 1-4 regional lymph nodes

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6
Q

What is Duke Stage C2?

A

Spread to more than 4 regional lymph nodes

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7
Q

What is Duke Stage D?

A

Distant metastases

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8
Q

What is the most common type of oesophageal cancer in the developed world?

A

Adenocarcinoma

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9
Q

What is the most common type of oesophageal cancer in the developing world?

A

Squamous cell

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10
Q

What can cause adenocarcinoma in the oesophagus?

A

GORD, Barrett’s, smoking, obesity

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11
Q

What are risk factors for oesophageal cancer?

A

Achalasia, alcohol, obesity, smoking

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12
Q

Where do each type of oesophageal cancer occur?

A

Adenocarcinoma - lower 1/3, squamous cell - upper 2/3

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13
Q

How does oesophageal cancer present?

A

Vomiting, progressive dysphagia, anorexia and weight loss

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14
Q

What are ALARM symptoms?

A

Anaemia, Loss of weight, Anorexia, Recent onset progressive symptoms, Melaena/haematemesis, Swallowing difficulties

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15
Q

What is the first line investigation in oesophageal cancer?

A

Upper GI endoscopy and biopsy

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16
Q

What imaging do you use to stage oesophageal cancer?

A

CT or endoscopic ultrasound

17
Q

How do you manage operable oesophageal cancer?

A

Surgical resection and adjuvant chemotherapy

18
Q

What is type 1 gastric cancer?

A

Intestinal and differentiated

19
Q

What is type 2 gastric cancer?

A

Diffuse and undifferentiated

20
Q

What are risk factors for gastric cancer?

A

Male, H.pylori, chronic gastritis, blood type A

21
Q

What does type 1 gastric cancer look like and where is it found?

A

Large and irregular in antrum and lesser curvature

22
Q

What does type 2 gastric cancer look like and where is it found?

A

Submucosa invasion found anywhere but especially the cardia

23
Q

How does gastric cancer present?

A

Anorexia, nausea, weight loss, anaemia, dysphagia, vomiting, epigastric pain,

24
Q

What is the gold standard investigation in gastric cancer?

A

Gastroscopy and biopsy

25
Q

How would you image the depth of invasion in gastric cancer?

A

Endoscopic USS

26
Q

How do you manage gastric cancer?

A

Nutritional support, surgical resection, chemo

27
Q

What are risk factors for colon cancer?

A

FH, IBD, Poor diet, obesity, DM

28
Q

What is the first line investigation in colon cancer?

A

Faecal occult blood test

29
Q

What is the gold standard investigation in colon cancer?

A

Colonoscopy + biopsy

30
Q

Where is colon cancer found most often?

A

Distal colon

31
Q

How does colon cancer present?

A

Pain, mass, bleeding, change in bowel habit, weight loss, vomiting, obstruction

32
Q

How do you manage colon cancer?

A

Resection and chemo