Coeliac Disease Flashcards
What gene do 95% of people with Coeliac have?
HLA DQ2
What skin condition is associated with CD?
Dermatitis herpetiformis
How does CD cause pathology?
T-cell response to prolamin in gluten in the upper small bowel causes villous atrophy, crypt hyperplasia and malabsorption
What stool signs could there be?
Stinking stools, steatorrhoea, diarrhoea
What abdominal signs/symptoms could there be?
Abdo pain, bloating, nausea and vomiting
What general signs/symptoms could there be?
Wt loss, fatigue, weakness, anaemia, osteomalacia, angular stomatitis
What is the first line investigation?
Serum antibody testing for IgA tissue transglutaminase
What investigation is the gold standard?
Endoscopy with duodenal biopsy while on gluten-containing diet
What would you expect to see on a duodenal biopsy/endoscopy?
Villous atrophy, increased intraepithelial WBCs, crypt hyperplasia
How would you manage CD?
Lifelong gluten-free diet
How do you monitor CD?
Track symptoms and repeat serology
What are some potential complications of CD?
Anaemia, osteoporosis, hyposplenism, neuropathies, Increased risk of T-cell lymphoma, gastric, oesophageal, small bowel and colorectal cancer
What are risks for Coeliac disease?
FH, HLA, other autoimmune diseases, IgA deficiency
What blood results would you expect?
Low Hb/folate/ferritin/B12
Why would you do a DEXA scan?
Increased risk of osteoporosis
