GI and Liver Flashcards
1
Q
What type of injury can the liver recover from?
A
Acute injuries are usually recovrable
2
Q
Wat can cause acute liver injury?
A
Viral (A,B,EBV) drugs alcohol vascular ubstruciton or congestion.
3
Q
What can cause chronic liver failure?
A
alcohol Viral (B, C) autoimmune metabolic (iron, copper)
4
Q
What are symptoms of acute liver injury?
A
Malaise nausea, anorexia, jaundice rarely confusion bleeding liver pain and hypoglycaemia
5
Q
What are the presentation of chronic liver failure?
A
Ascites oedema, haematemesis (varicies, malaise, anorexia, wasting, easy bruising, itching hepatomegaly, abnormal LFTs rarely jaundice and confusion
6
Q
What tests can gage liver function?
A
Serum bilirubin albumin prothrombin time as liver is involved in those pathways.
Serum liver enzymes like cholestatic alkaline phosphatase and gamma-GT hepatocellular transaminases give no index of liver function
7
Q
What causes jaundice/
A
raised serum bilirubin
8
Q
What are the types of jaundice?
A
Unconjugated prehepatic, from gilberts syndrome or haemolysis
Conjugated from cholestatic liver disease or bile obstruction so called post hepatic
9
Q
What can be tested in liver tests?
A
Stools urine, itching and liver tests
10
Q
What would be seen in urine stools LFT for prehepatic?
A
Normal urine normal stools and no itching and normal LFT
11
Q
What wpuld be seen in urine stools LFT for hepatic or post hepatice?
A
Dark urine pale stools may itch and abnormal LFTs
12
Q
What can cause liver disease?
A
Hepatitis (Viral, Drug, Immune, Alcohol) Ischaemia, Neoplasm congestion
13
Q
What can cause obstruction of the bile duct?
A
Gallstones bile duct or Mirizzi, stricutre malignant or ischaemic inflammatory
14
Q
What should you ask a patient with jaundice/
A
Dark urine pale stools itching? symptoms biliary pain rigors abdomen swelling weight loss, billlary disease intervention history, heart failure blod products autoimmune diseases and malignancy
drugs socual including sex IV drugs alcohol family history
15
Q
What to test in pt with jaundice?
A
LFTs, Ultrasound for bile ducts, may need CT MR choliangiogram or endoscopic retrograde cholangiogram
16
Q
What are gall stones made of?
A
70% choesterol 30% pigment+/- calcium,
17
Q
What are risk factors for gall stones?
A
Femail fat fertile
18
Q
What are symptoms of gallbladder gallstones?
A
Billary pain cholecystitis, myabe have obstructive jaundice no cholangitis or pancreatitis
19
Q
What is the presentation of gall stones in the bile duct?
A
billary pain no cholcystitis, no obstructive jaundice no cholangitis and no pancreatitis
20
Q
How can gall stonesbe managed/
A
Laproscopic cholecystectomy, bile acid disolution therapy, if in bile ducts ERCP with sphincterotomy and removal crushing or stent placemt or surgery
21
Q
What the types of drug induced liver injury?
A
Hepatoceular where ALT is v high and ALT/ALK hos high
or cholestatic were it is ALK phosphatase> 2
22
Q
When can drug induced liver injury happen/
A
Within 3 months of starting can happen after stopped, resolution within 3 months of stopping
23
Q
What are the usual suspects for drug induced lier injury?
A
antibiotics, CNS drugs immunosupressants analgesics GI drugs suppliments
24
Q
What is management of paracetamol induced fulminant hepatic falure?
A
N acetyl Cystine, Supportive to correct coagulationd defects fluid electrolytes and acid base balance renal failurem hypoglacaemia and encephalopathy
25
What can cause ascites?
Chroic liver disease portal vein thromboses hepatoma TB neoplasia of abdominal organs, pancreatitis, cardiac causes
26
Why does acites happen?
Systemic vasodilatation, increased fluid retention pertal hpertension low serum albumin
27
Do all alchol drinkers get alcholic liver disease?
No only 10 -20% of heavy drinkers
28
What can cause portal hypertenison?
Cirrhosis, fibrosis portl vein thrombosis from increased hepatic resistance or increased splanchnic blood flow
29
What are consequences of portal hypertension?
varicies splenomegaly
30
Why are chronic liver disease patients vulnerable to infection?
They have impared reticulo-endothelial function, reduced opsonic activity, leucocyt function, permeable gut wall
31
Is jaundice obvois?
No very unlikely
32
What is rigors?
increased temperature with shivering
33
How long for a good drug history?
6 months if possible
34
What does raised AST or ALT mean?
Might be due to liver
35
What is colic pain?
Coming in waves
36
What are pathologies for drug induced liver injury?
can be directly toxic othertimes ideosyncratic
37
What is a spider naevus?
brown diffuse area, it blanches
38
What is finding of acitic fluid for liver diseases?
Serum albumin is low and fluid is same
39
Hw can ascites be managed?
Fluid and salt restriction, diuretics, large-volume paracentesis+albumin, trans-jugular intrahelatic portosstemic shunt.
40
What is acute decompensation?
Symptoms such as formation of acites encephalopothy and bleeding when liver stops functionng correctly
41
When do most people die from alcohol related deaths?
50s to 70s
42
How long does it take for alcohol withdrawal symptoms to appear?
3 days use a withdrawl medications
43
What can precipitate liver disease decompenastion?
Constipation, Drugs sedatives analgesis NSAIDs diuretics ACE blockers GI bleed Infection, Hypo natraemia kalaemia glycaemia, alcohol withdrawl, other
44
What is spontaneous bacterial peritonitis?
Commonest serious infection in cirrhosis, vagues symptos often suspected from neutrophils in ascitic fluid, gram stain often negative use blood culutre bottules after 1 episonde should have prophylaxis and consider for transplant
45
What is renal considération liver disease?
Renal failure is common review drugs my need review of doses and drugs
46
What is hepatic encephalopathy?
Raised ammonia levels from infection GI bleed constipation hypokalaemia dru induced, hyponatramea hypohlycaemia or a stroke
47
WHat are the bedside tests for encephalopathy?
subtract 7, 10 animals in a minute draw 5 point star number connection test, world backwards
48
What happens with livr dysfunction?
Malnutrition, coagulopathy, cholestasis causes thrombocytopenia, endocrine changes gynacomastia impotence amenorrhoea hypoglycaemia
49
What to thinl about in a patient with liver disease?
be careful of drugs prescriptions, pain medication may need reducing, kidney injury
50
What is non-invasive liver screen?
autoantibdies, imunoglobulins, hepatitis B surface antigen C or virus biochemisty iron studes copper alpha1 antitrupsis lipids glucose
51
What are hepatitis differential diagnosis?
Alcholo autoimmune virology, drug induced
52
What is autoimmune hepatitis treated?
Steroids to surpress it
53
What are the types of autoimmune liver diesases?
Scerosisn colangitis, autoimmune hepatitis afectin hepataocytes, primary biliary cholangiatis
54
What can help with autoimmune liver dieases diagnois?
Family history of autoimmune disease and current other ones
55
what is the epidemiology of autoimmune disease?
mainly women
56
How can you treat cholestatic itch?
Antihistamines lotions,
57
What blood disorder can affect the liver?
Iron can build up in haemochromatosis can include genetic screening for the rest of the family
58
What is alpha 1 antitrypsin deficeincy?
inability to export alpha 1 antitrypsin from liver can cause liver disease and empysema, asthma
59
What is hepatocellular carcinoma?
Cancer of the liver cells Usually associated with in hepatitis BC haemochromotosis and usually already have cirrhosis, can cause decompensation,
60
What is non alcoholic fatty liver disease?
Build up of fat in the liver treated by weight loss improve diabetic control
61
What are non alcoholic fatty liver disease risk factors?
Obesity diabetes hyperlipidaemia
62
Where are most of the bacteria in the GI tract?
After the duodenum as gastric acid restricts the growth of organisms before this point
63
What do the intestinal microflora do?
Out compete pathogenic bacteria produces,mainly anaerobes, can produce antibacterial substances bile and gastric acid have antibacterial properties
64
What is diarrhoea?
Fluid or watery stools in 3 or more tiems in 24 hours can be watery or bloody
65
What is dysentry?
Bloody diarrhoeas with stomach pains
66
What non-infectious causes can casue diarrhoea?
Cancer cheical poising, inflammatory bowel diseae endocrine and dietary
67
What is the mechanism of diarrhoea by pathogens?
Adherence to epithelium in proximal small bowel and produciton of enterotoxin.
68
What usually causes bloody diarrhoea?
Bacteriain the colon, viruses rarely cause this
69
What are the most common cause of diarrhoea in the UK?
Viruses such as rotavarius in childrenand norovirus (highly infectious)
70
What are the bacterial causes of watery diarrhoea?
Cholera not in the uk, Enterotoxifenic E.Coli most common traveller's diarrhoea Cperfringens Bacillus cereus reheated rice/vomiting staphylococcus all by food poisioning
71
What infections agent can cause persistent diarrhoea?
Giardia a parisite occures worldwide common in areas of por sanitation
72
What can cause bloody diarrhoea?
Slamonella from undercooked poultry eggs and upasturised dairy, shegella, person to person spread crowded living conditions and E.coli Entero invasive and shialike toxin producing, can cause haemolysis Campylobacter and yersina
73
How does shigella cause damage?
Shiga toxin that dammages bowel surface
74
What is colostroides difficile?
Spore producing toxin producing gram positive bacteria often after antibiotics that allow them to thrive
75
When does C diff infection happen?
up to one month after, asymptomatic carriage and can lead to toxic megacolon
76
How ar Cdiff treated?
Cessation of broad antibiotics, vancomycin metronidazol and barrier precations
77
What are key parts of history for diarrhoea?
Travel onset and duration characteristics of stools, hobbies, animal contacts, urine output drinking, medications
78
What are indications for testing of diarrhoea?
Signs of hypovalaemia, severe abdo pain, bloody diarrhoea+ mucus in high risk patients IBD pregnancy, more than 1 week symptoms public health concern eg if in food handler
79
What does the lab do to for testing stool?
microscopy, cuture, Multi-pathogen molecular panels, ova cysts parasites, toxin detection C difficile, blood for culture inflammatory markers electrolytes creatimine
80
What is main way of treating patients with diarrhoea?
hydration and electrolytes, may need to notify PHE, dont often give antibiotics, giardia, c diff and salmonella
81
What to do to guide intrabdominal infection investigation?
Pain location and other symptoms
82
What is acute cholecystitis?
Gallbladder inflammation cystic duct obstruction by gall stones, RUQ or epigastric pain fever and leucocytosis,
83
How is acute cholecystitis diagnosis treatment?
ultrasound IV fluids and analgesia and antibiotics or surgery with cholecystectomy
84
What is ascending cholangitis?
Obstruction of common bile duct with pain fever and jaundice charcots triad, Managed by IV antibiotics prompt admission ERCP or cholecystectomy
85
What are liver abscesses types?
Pyogenic following biliary sepsis usually polymicrobial enteric gram-negative bacilli and anaerobes can be amoebic occasionally
86
What are presentation of liver abscess?
Fever RUQ pain nausea vomiting anorexia weight loss and malaise
87
How is liver abbesses diagnosed and treated?
CT or ultrasound, blood cultures of the abscess material and E histolytica molecular testing.
88
What is the treatment of a liver abcess?
Drainage and antibiotics
89
What can cause peptic ulcers?
Helicobacter pylori adheres to gastric epithelium it is very common half have it it can cause dyspepsis and epigastric pain and is associated with gastritis, gastric adenocarcinoma and gALT lymphoma
90
What causes genaralised abdomainal pain/
Peritonitis ainflammation of peritoneaum due to infectin or inflammaton can be acute sever generalised abdominal pain with fever and diffuse abdominal tenderness and rigidity and guarding
91
What are the classes of peritonitis?
Primary (spontaneous) from acites TB PID and cirrhosis
| Secondary from spillage from GIT in trauma or appendicitis and peritonitis secondart to ambulatory peritoneal dialysis
92
What is the presentation of enteric fever?
Generalised abdominal pain fever and chills, headache and myalgia and relative bradycardia rose spots constipation/green diarrhoea blood culture and bone marrow aspiration
93
What are complications of enteric fever?
GI bleed perforation myocarditis and abscesses
94
What is important in diarrhoea?
Travel history and antibiotics
95
What are general mechanisms of intestinal obstruction?
Intraluminal, Intramural extraluminal
96
What can cause intraluminal obstruction?
Tumour carcinoma lymphoma, diaphragm disease (related to NSAIDS fibrotic action), gallstone ileus (rare), meconium ileus
97
What can cause intramural obstruction?
diverticular disease, Crohn's disease, Intramural tumours, Hirschprung's disease
98
What is hirschprung's disease?
When there is no ganglia so it is not innervated anganglionic bowel
99
What can cause extraluminal obstruction?
Adhesions often from surgery a long time ago, sigmoid volvulous ( twisted colon then obstructed itself), peritoneal tumour (ommentum potentially)
100
How common is intestinal obstrucion?
5-20% of emergency general surgery.
101
What is prognosis for obstructed bowel?
quite good when treated, around 30% mortalitiy for most types
102
What are key parts of anatomy to be aware of in the abdomen?
Greater sac and lesser sac, ommentum
103
What are the physiological characteristics of the bowel?
Distensibility, motility, segmented peristalsis, it has sphincters, secretions take place
104
What is intussusception?
telescoping of the bowel
105
What is intussusception?
telescoping of the bowel
106
What are the ways the bowel obstruction are classified?
Site, extent partial/complete, anchoring to mechanism, mechanical or paralytic pseudo, according to pathology simple closed loop strangulation intussusception
107
Where is intussusception most common?
small or large bowel
108
What are the symptoms of bowel obstruction
poorly localised pain, colicky cramping pain, vomiting early in proximal bowel or llate in distal, constipation early in distal of bowel and late in small bowel abdominal distension
109
What are clinical findings of bowel obstruction?
Tachycardia from dehydration low pulse pressure, abdominal (distension visible peristalsis obvious lump at the site of obstruction)
110
What is paralytic ileus?
failure of peristalsis, no mechanical obstruction, can be caused by hypocalcaemia post operative,
111
What is gastric outlet obstruction?
uncommon benign or malignant, chronic peptic ulcer distal gastric cancer, hypertrophic pyloric stenosis gastric paresis
112
What is the most common cancer of the bowel?
Carcinoma
113
Who does bowel cancer usually affect?
mainly older people and often western countries
114
What structure can lead to colorectal cancer?
Adenomas of the bowel, polyps
115
What are the genetic conditions that predispose to colorectal cancer?
Familial adenomatus and polyposis
| hereditary nonpolyposis colorectal cancer
116
What is Familial adenomatus polyposis?
Gorw thousands of polyps and can lead to getting adenocarinoma, caused by genetic mutation to gene that produces a protein that usually removes beta catenin so with mutation it builds up in the protein causing polyps from epithelial proliferation
117
Why look for identification of HNPCC?
risk of further cancers in index patient and relatives, can affect therapy, tolerance of treatments
118
Where does colorectal cancer occyr/
Mainly in the rectum rectosigmoid, meanin cn be easily felt by digital rectal examination, adenocarcinoma
119
How is colorectal cancer staged?
resection margins Resection coding R0 completely R2 not all removed,
120
How are cancers graded?
invasion on T and N baste on node metastases M
121
What are presentation of small bowel obstruction?
vomiting sometiems faeculent, collicky or constant diffuse pain constipation but is a late complication distension and tenderness
122
What is the presentation of large bowel obstruction?
abdominal discomfort, fullnes bloating nausia altered bowel habit blood in stoolsa, colicky pain tender, nausea its often from malignancy, late is vomiting if its volvulus it is sudden pain localised tenderness and distension
123
What are mechanisms of obstricuion/
Mechanical/true intra or extraluminal and parylitic
124
What is small bowel obstruction pathophysiology?
proximal dilatation,Increased secretions + swallowed air, with dilatation get less absorption and mucosal wal oedema, increased pressure - intramural vessels compressed leading to ischaemia and perforation
125
If perforation occurs where is it most likely?
In the caecum
126
What happens in large bowel obstruction?
Distension of all areas up to the blockage
127
What can cause prehepatic jaundice?
Breakdown of blood in excess from malaria, sickle cell anaaemia and foetal Hb breakdown in newborns.
128
What can cause hepatic jaundice?
failure of hepatocytes to take up or excrete bilirubin. dark urine and normal/ale stools increased
129
What are the local complications of ulcerative collitis?
carcinoma rupture of the bowel, massive haemorrhage.
130
What are the local complications of crohn's disease?
fistula, abscess formation, stenosis/ strictures, carcinoma, lymphadenopathy
131
Where can Crohn's disease affect?
The whole GI tract
132
Where can ulcerative colotis affect?
The large bowel/ colon only
133
What is the pathophysiology of inflammatory bowel disease?
M cells usually sense the microbes in the gut to activate the immune system by using antigen presenting cells, and or impared barrier function allowing microbes into the walls. then inflammation ensues
134
What environmental factors can affect Crohn's disease and ulcerative colitis?
Microbes, diet infections stress NSAIDs smoking antibiotics
135
What environmental factors can affect Crohn's disease and ulcerative colitis?
Microbes, diet infections stress NSAIDs smoking antibiotics
136
What is the inflammatory process in the bowel wall?
Antigen presentign presents to t cells and activates mroe APC and causes cytokine function and release including, TNF alpha, IL-1 and 6
137
What are the effects of TNF alpha on the bowel mucosa?
Paneth cell necrosis(releases antimicrobials) angiogenesis, Intestinal endothelial cell death and increaes immune response and cayses myofibril induced destruction
138
What are the systemic complication of IBD active phase?
Conjunctivitis, irisis, mouth ulcers, fatty liver/absecss, meseteric or portal vein thrombosis, venous thrombosis, large joint arthritis, erythema odosum and pyogenia gangreousum result of cytokine release
139
What are the investigations for IBD?
FBC (anaemia and malabsorption) blood chemistry (decreased albumin) ESM.CRP (inflammatory markers) MCS stool microbes to rule out infection, gold standard is endoscopy- colonoscopy
140
What is the features of colonoscopy for ulcerative colitis?
eythematus appearance, continuous lesion pseudopolyps, petuciae exudates and oedema
141
What are the features of Crohn's disease on endoscopy?
Cobblestone appearance strip lesions pseudopolyps granulomas
142
What can you do to investigate Crohn's disease severity?
Radiology looking at barium studies to stage the disease
143
How is Ulcerative colitis diagnosed?
Chronic diarrhoea for 4 wees and evidency of activ inflamation on endoscopy and chronic changes in biopsy.
144
What is needed for Croh'ns disease dianosis?
endoscopic findings and immagins study with clinical history
145
what are the aims of treating IBD?
treat attacks and prevent relapse
146
How can IBD be treated?
5- ASA terapy +- corticosteroids it is activated by colon bacteria and it reduces local inflammation. In severe issues, rehydration, and corticsteroids, no 5-asa, antibiotics or tnf-alpha inhibitors ca remove part of colons
147
What are treatments for chrons?
Prevention, imune surpresssion diet TNF alpha antagonists, mantenance methotrexate surgery for complications of chrons and to remove sectins of damaged bowel
148
What is gluten sensitivity enteropathy?
Coeliac disease gluten allergy
149
What is gluten?
Found in wheat barley and rye makes doeugh elastic and binding
150
What are the symptoms of coeliac disease?
when gluten is eaten the villi shorten and lots of intraepithelial lyphcytes prolferate. gluten initiates autoimmune reaction that shortens and atrophies villi and deapens crypts itstops water and fat absorption to cause diarrhoea and steatorrhea, weight loss fatigue anaemia ostoporosis increased risk of bleeding al from malabsorption
151
What are rare complications of coeliac disease?
neurological disease, cancers and infertility
152
What is the pathophysiology of coeliac diseae?
Gluten isn't broken down properly as has lots of proline and glutamine. The large molecules can be transported by receptors between the cells or dammage the epithelium. then they are modified by an enzyme and glutamate is produced and immune system attacks this
153
What is the immune response like in coeliac disease?
make antibodies against glutamate and cause autoantibodies for glutamate and the enzymes and causes damage to enothelium for t cell cytokines
154
What makes coeliac immune problems?
the type of MHC II molecules they have HLA-DQ2 and 8 having this mutation and need environmental and genetic factors to contribute to it
155
How is coeliac disease treated?
avoid gluten at all costs and will cure them
156
How is coeliac disease diagnosed?
common in autoimmune diseases, and family history MS and type 1 diabetes the antibodies against transglutaminase but not 100% endoscopy is the most sensitive villus blunting and crypt hyperplasia
157
What can cause malabsorption relating to the duodenum?
pancreatic failure from pancreatitis, bile salt production failure lack of digestive enzumes defetive epithelial transport, lymphatic obstruction TB or lymphoma
158
What can cause damage to the absorptive surfaces of the bowel?
Chron's disease, IBD and coeliac disease, small bowel infarction
159
What is extensive surface parasitisation?
Giardia lamblia a protazoa can cause the intestine to be damaged
160
What is chronic idpathic inflamatory bowel?
Name for Crohn's andIBD
161
What are the complications of Crohn's disease?
Malabsorption disease extent surgical resection, obstruction from fibrosis, perforation, fistula formation anal skin tags fissure fistula neoplasia
162
What type of inflammationos Crohn's disease?
Transmural inflammation
163
What type of inflammationos inflammatory bowel disease ulcerative collitis?
only in large intestine long strips and only affects epithelium
164
What are the symptoms of upper GI cancer?
They are like gastritis general pains dyspepisa etc
165
What is Barret's oesophagus?
Metaplasia change of cell types from differentiated to another differentiated type it is also called columnar lined lower oesophagus
166
What makes Barret's oesophagus likely?
Obesity, males
167
What are the stages of changes of oesophagus cancer formation?
normal tissue then GORD gives Metaplasia into glandular epithelium, then more GORD and other factors lead to dysplasia and then neoplasia
168
How to treat oesophageal cancer?
Surgery removal if posible
169
Why is oesophageal cancer got very bad outcomes?
It presents very late as the symptoms don't come till later
170
What are the risk factors for gastric cancers?
smoked pickled food? disease of later life age related, sometiems helicobacterpylori
171
What are the stages of adenocarcinoma in the stomach?
normal mucosa is disrypted by H Pylori or other factors then has intestinal metaplasia then dysplasia happens and you get genetic changes eating to intramural carcinoma then invasive carcinoma
172
Why does gastric cancer present late?
the tumour can get very large before symptoms become present
173
What can happen to the gastric mucosa in ischaemia?
they stop producing enough mucous and can begin to cause an ulcer which can cause pain
174
When is mucosal ischaemia likely?
Patients i haemodynamic shock
175
What can cause gastritis?
ischaemia, excessive acid production (stress, Helicobacter) aspirin can cause inhibition of mucosalproduction, bile reflux, alcohol,
176
Where do H.pylori live?
In the mucin layer they induce acid production and neutrophils to enter gastric cells
177
What is important about pain sensation in the abdomen?
The parietal gives well localised pain the visceral only gives generalised pain
178
What are the functions of the peritoneum in health and disease?
In health,visceral lubrication fluid and particulate absorption, in disease pain perception inflammatory and immine response and fibrinolytic activity
179
How can peritonitis be classsified?
Acute onset chronic onset or primary or secondary
180
What can cause peritonitis?
Bacterial from GI or other, Chemical, bile leakage or barium, Traumatic from operations/surgery, ischaemic from strangulated bowel or vascular occlusion or familial mediterranean fever
181
How can the peritoneum become infected?
From GI ( commonly perforated ulcer, appendix, diverticulum) transmural translocation no perforation in ischaemic bowel primary bacterial peritonitis andpancreatitis, exogenous contamintation from dialysis, open surgery, trauma or drains From the femal genital tract infection or hamatogenous spread from a blood borne infection
182
What microorganisms can cause peritonitis?
E. coli, streptoccoci Enterococci bacteroides, clostridium klebsiella
183
What are the clinical features of localised peritonitis?
Pain, nausea and vomiting, fever, tachycardia localised guarding rebound tenderness shoulder tip (supphrenic) pain and tender rectal and or vaginal examination
184
What are the early features of diffuse eritonitis?
abdominal pain, worse by moving, tenderness generalised guarding infrequent bowel sounds paralytic ileus, fever and tachycardia
185
What are the late features of diffuse peritonitis?
Generalised rigidity, distentsion absent bowel sounds, ciculatory failure thready irregular pulse Hippocratic facies and loss of consciousness
186
What investigations are needed for peritonitis?
Urine dipstix for UTI, ECG if diagnostic doubt to rule out cardiac event. Bloods U&E FBC serum amylase for pancreatitis, group and save. CT abdo or CXR
187
What is the key diagnosis of coeliac disease?
villus atrophy intraepithelial lymphocyte increase and crypt hyperplasia
188
How are patients with peritonitis treated?
Correction of fluid loss and circulating volume, urinary catherterisation and GI decompression antibiotics and analgesia renal support
189
What is familial Mediterranean fever?
genetic autoinflammatory disease affecting lungs joints and abdomen mainly in 20-40, more women than men and in certain groups such as
190
How much ascites is normal?
In men usually none women around 20mls is normal
191
What are the classifications of ascities?
Staged 1-4, detectable only after careful examination/ultrasound, easily detectable but small volume, obvious non tense ascites and tens ascites
192
What are the two types of ascites?
Transudatw with low protein and exudate with high protein
193
What are transudate causes of ascites?q
Low plasma protein in malnutrition, nephrotic syndrome or protein losing eneropathy hich central venous pressure and portal hypertension.
194
What are the causes of exudate ascites?
Peritoneal malignancy, tuberculosis peritonitis,Budd-chari syndrome, pancreatic ascites,
195
Where are most cases of ascited found?
In liver cirrhosis then cancer
196
What are clinical presentations of ascites?
Abdominal distension, gaining weight clothes getting tighter, nausea/loss of appetite, constipation wasting, pain and discomfort painful in malignant, and symptoms of underlying cause
197
What are clinical tests for ascites?
Shifting dullness fluid sonds on tappingflank fullness
198
What are investigations for ascites?
Usually part of general ones for underlying cause, utrasound most sensitive ascitic aspiration and testing of fluid
199
How are ascites treated?
Diuretics, treatment of cause sodium restricution paracentesis indwelling drain
200
What are the main types of biliary tract disease?
Gallstones- biliary colic, Cholecystitis, Cholangitis
201
What symptoms are used to differentiate biliary tract disease?
Virchow's triad- Right upper quadrant pain, Fever/incr WCC, jaundice
202
Which symptoms of Virchow's triad come with Gallstones?
RUW pain
203
Which symptoms of Virchow's triad come with Acute cholecystitis?
RUQ pain and fever
204
Which symptoms of Virchow's triad come with Cholangitis?
all three RUQ pain, fever WCC and Jaundice
205
What is the pathophysiology for gallstones/biliary colic?
Blockage of the cystic or common bile duct without signs of cystic inflammation the stones are made of cholesterol pigment or both
206
What are the qualities of biliary colic/ gallstones?
Colicky RUQ pain ofte after eating large or particularly fatty meals which trigger the gallbladder, pain can radiatd to epigastrium and back
207
What investigations are needed for biliary colic/gallstones?
FBC, CRP, LFT Alk phos Amylase to check for pancreatitis, to confirm need ultrasound look for stones gallbladder wall thickness and duct dilatation,
208
How is gallstones treated?
NSAIDs analgesia, optional cholecystectomy, removal
209
What is cholecystitis?
Stone blocking the duct bile builds up distending gall bladder and vascular supply can be afected leading to inflammation of the gall bladder
210
What are the signs and symptoms of cholecystitis?
Generalised epigastric pain to severe RUQ fever or fatigue pain associated with tenderness and guarding from inflamed gall bladder and local peritonitis
211
What is a specific clinical sign for gall bladder problems?
Positive murphy's sign
212
What is cholangitis?
Blocked bile duct because bile isnt pasing through the duct so bacteria ascend fromthe gut and infect it can affect pancreas too
213
What are the signs and or symptoms of Choangitis?
Sever RUQ pain, fever with rigors and jaundice. Patient may present as septic or have developed pancreatits
214
What to do to treat cholangitis?
Treat sepsis, ERCP to clear blockages and might remove gall bladder
215
What is acute pancreatitis?
self-perpetuating inflammation of the pancreas causing leakage of enzymes and autodigeston the ancreas can heal after breif acute episodes
216
What is the pneumonic for acute pancreatitis?
I GET SMASHED
Idiopathic, Gallstones, Ethanol, Trauma, Steroids, Mumps, Autoimmune(japan), Scorpion venom, Hyperlipidaemia, ERCP, Drugs NSAIDs ACEi Steroids
217
What is the pathology of acute pancreatitis?
Alcohol contracts Ampulla of vater bstructing bile clearances and messes with Ca2+ homeostasis.
Gallstoens block bileduct and pancreatic duct causes Ca2+ relseae in oancreatic cells to actuvate tripsinogen that digests the pancreas
Also damage can lead to a leaky pancreas, causing autodigestion, can cause pancreatic dyfunction leading to hyperglycaemia
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What is the presentation of pacute pancreatitis?
Severe epigastric pain radiating to the back, anorexia fever jaundice Grey turners sign, N&V tachycardia
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What are the investigations for acute pancreatitis?
Serum amylase urinary amylase serum lipase which is more specific CRP and routine bloods erect CXray abdominal ultrasounds and CT, MRI
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How is pancreatitis treated/
Nil by mount to drop stimulation, prophylactve antibiotics analgesics, if gallstones are the cause treat them
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What is chronic pancreatitis?
Generally caused by chronic alcohol abuse but can be hereditary autoimmune or from CKD, obstructs bicarbonate secretion causes early activation of trypsinogen and autodigestion of pancreas and fibrosis,
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What is the presentation of chronic pancreatitis?
Epigastric pain boring through the back, worse after alcohol better leaning forward, usually 50+ maleHistory usualy fits, nausea vomiting decreased appedite malabsorption
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What are treatments for chronic pancreatitis?
stop drinking pancreatic enzyme supplements and PPI to aid digestion insulin for Diabetes and duct drainage
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What can cause infective diarrhoea?
Viral, bacterial, paneatic, antibiotics C diff,
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What are the risk factors for infective diarrhoea?
Foreign travel poor hygiene and crowded area
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What is haemochromatosis?
Too much iron in body cant store properly so end AR inheritance
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When does haemochromatosis present?
40s and later in women due to menstruation
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What is the presentation of haemochromotosis?
Chronic tiredness, Joint pain, pigmentation of skin, hair loss, sexual problems, cognitive problems, mood disturbance pancreas problems
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How is hameochromotisis?
Genetic testing to confirm, transferrin, and ferratin levels
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What is wilson's disease?
Too much copper in liver and CNS
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Wat is the pathophysiology of Wilson's disease?
Error of copper matabolism copper is deposited in liver basal ganglia and cornea
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What is the presentation of wilson's disease?
Depression, neurotic behavioural patterns, CNS problems tremor dysarthria involuntary motions reduced memory, hapatitis cirrosis, Kayser-Fleischer ring copper in cornea
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What investigations are needed for Wilkinson's diagnosis?
Serum copper and ceruloplasmin reduced, 24hour urinary copper excretion high, liver biopsy
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What is the treatment for Wilkinson disease?
Avoid high copper foods, use Chelating agent, Penicillamin or liver transplant
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What is alpha 1 antitrypsin deficiency?
autosomal recessive may result in lung and liver disease protease inhibitor that inhibits elastase. It causes COPD like symptoms with emphyseuma, bronchiectasis, chronic bronchitis
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What are complications of alpha 1 antitrypsin deficiency?
COPD lung dammage mucous chronic cough, liver disfynction, toxin buildup prota hypertension
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How to investigate alpha 1 antitrypsin deficiency?
Bloods serum A1AT CXR pulmonary functon tests liver function tests and liver biopsy
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How is A1ATD treated?
treat liver problems, and lung problems as symptomatic
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What is the pathophysiolgy of acities?
Excessive buildup of fluid in the peritoneal cavity from poor liver function and low albumin, low oncotic pressure, leads to fluid losss to the peritoneal cavity.
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What is the presentation of acites?
Large distended abdomen, shifting dullness
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How to treat ascites?
Low sodium diet spironolactome and furosimede and identyfy and treat cause
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How can peritonitis occur?
Spontaneous bacterial infection, secondary o perforated bowel or appendice or GU tract
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Where are the sites a hernia can take place?
epigastric, umbilical spigelian inginal femoral or obturator
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What are the complications of hernias?
Obstruction and strangulation of the bowel
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How do inguinal hernias occur/
Direct uncommon passes through posterior wall direct is medial to the inferior epigastric artery and indirect is lateral to it
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What are the symptoms of a hernia?
Swollen lump, discomfort in the gut, pain in abdomen, constipation and expands on coughing
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What is acute appendicitis?
infection of it it is surgical emergency
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What can cause appendicitis?
faecoliths, bezoars foreighn bodies trauma intestinal worms or lymphoid hyperplasia. leads to swelling and infection
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What is clinical presentation of Acute appendicitis/
early pain discomfort around umbilicus then passes towards tight illiac fossa to mcBuneys poing can be les severe, get guarding tender mass in RIF pyrexia anorexia nasusa and vomiting rosvings sign pain on movment and coughing
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What investigations are needed for Appendicits?
FBC raised WCC Raised CRP ESR less likely ultrasound can ddetect but gold standart is CT
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How is acute appendicitis managed?
Appendiectomy is gold standard IV antibiotics
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What is complicatin of acute appendicitis?
Perforation appendix mass, adhesions PID
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What is clinical presentation of ischaemic bowel disease?
Acute sever abdo pain, no abdo pain hypovalaemic shock often out of proportion symptoms with signs
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What is likely to case memsenteric schaemia
Superior mesenteric artery embolismu of ten from Atrial fibrilation
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What is gold standard for diagnosisng coeliac?
Duodenal biopsy
