GI 6 Flashcards

0
Q

Hypovolemia consequences

A

Tissue ischemia ➡️ metabolic acidosis ➡️ circulatory collapse/shock
(but ⛔️early protracted vomiting)

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1
Q

Causes of HYPOvolemia

A

Diarrhea, hemorrhage, vomiting, NaCl & H2O depriv, excessive sweat, renal disease

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2
Q

Mech Diarrhea

A
SODIM
Filt Secretion: ab.Starling F
Osm diarrhea
Secretory dia
Inflammation 
Ab Motility
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3
Q

Low level Filt Secr

High level

A

Low: Chronic ISF loss
Protein losing enteropathy

High: diarrhea/ fl seq bowel

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4
Q

Causes of Filt Secr

A

VHVL

⛔️VR from intestines
Portal Hypertension
⏫volume (IV fluids)
Lymph obstr

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5
Q

Causes of Osm Diarrhea➡️paracell passive mov H2O

➡️Hypovolemia

A

CHO overload: ⏫VFA
Villi atrophy: mal dig/abs; bypass SI
➡LI: ️Excess fermentation

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6
Q

Secretory Diarrhea ➡️ Hypovolemia

A

Enterotoxins:✳️cAMP➡️
⛔️electroneutral NaCl abs & ✳️CFTR➡️ Cl & HCO3 secr

*Na-coup Nutri abs still active

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7
Q

Inflammation ➡️ Hypovolemia

A

Immune response

⏫WBC:⬆️PG➡️✳️cAMP ~Secr Diarr
Villi Damage➡️ Osm Diarr
Filt Secr

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8
Q

Ab.Motility ➡️Hypovolemia

A

Hypermotility: laxatives & IBM

&Hypomotility (most common)

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9
Q

️Hypovolemia compensation: fl. abs

A

SNS: ⛔️ENS & PSNS
Enkep interneurons
Aldo ➡️ LI

✳️segmentation: slow passage
⬆️fl abs ⬇️secr

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10
Q

Colonic Salvage

A

LI = large reserve capacity for electrolytes & fl abs (x3)

Impt colonic flora

Some SI Disease ➡️⛔️diarrhea symp

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11
Q

Pancreas

A

Endocrine: insulin (B) & glucagon (a)
Exocrine:
ecbolic secr➡️zymogens
hydrolatic secr➡️alk [HCO3]➡️neutralize GA

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12
Q

Neuro control of Pancr Secr

A

CGI
Cephalic: conditioned reflex➡️
PSNS➡️VIP(hydrolactic):✳️CFTR + Ach(ecbolic):✳️proenz

Gastric: food in stomach➡️
PSNS: ✳️VIP/Ach

(Prime) Intestinal phase:
Acid:⬆️Secretin+VIP➡️✳️cAMP
FA/AA in SI: ⬆️CCK+Ach:⬆️[Ca2+]

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13
Q

Pancreatitis

A

⛔️pancr duct flow➡️ autodigestion of ducts ➡️ leak proenz to blood & peritoneal cavity

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14
Q

Liver: CHO metab

A

Prime Fn: euglycemia

  1. Glycogenolysis (rapid)
  2. Gluconeogenesis
  3. Interconv monosacc
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15
Q

Liver: Nitrogen Metab

A

AA metab: TBDS
Urea metab: detox NH3
Uric Acid metab:

16
Q

AA Metabolism

A

TBDS

Transamin: syn noness AA
Bypass liver: gen circ of AA ➡️tissue
Deamin: NH3& c-skel➡️ gluconeogenesis
Syn proteins: hepatic & plasma (albumin/clot/A&B globulins)

17
Q

Ammonia intoxication

A
Liver disease
Urea poisoning (cattle)
Ornithine def(cats):req AA in urea cycle
18
Q

Uric Acid metabolism

A

Purines➡️Uric Acid➡️Allantoin➡️blood ➡️urine

19
Q

Liver: lipid metabolism

A

Maintains lipid input & output

I: chylomicra diet, syn FFA, adipose catabolism
O: lipoprotein, catabolism➡️Krebs, ketone body

20
Q

Lipoproteins

A

LDL: ⬆️TG ⬇️protein
HDL: ⬇️TH ⬆️protein