GI 2 Flashcards
Long Reflex: Inhibitory ⛔️
Slows transit ⛔️FB loop
⛔️overfilling of aboral segment
Organ Z➡️CNS:⬇️PSNS ⬆️SNS at Org X
Org Z:Org X Enterogastric Enteroenteric: distal SI:prox SI ⛔️peristalsis Coloileal Ileolgastric= "ileal brake"
Long reflexes: Stimulatory✳️
Gastrocolic Reflex: feed ⏩ loop
Full stomach➡️sig CNS:⬆️PSNS ⬇️SNS at Colon
⏫colonic motility➡️fill rectum
Gastrin/Cholecystokinin Family: GASTRIN
Endocrine
Ach/GRP/AA/pH>4✳️G-cell (antrum)➡️ Gastrin:CCK-b stomach
✳️parietal cell: HCl secr
✳️cheif cell: pepsinogen rel
⬆️gastric motility
Gastrin/Cholecystokinin Fam:
CCK-Pancreozymin
endocrine
AA/Fats in upper SI:✳️iCells➡️rel CCK:CCK-a➡️
- ✳️Pancr Acini: dig enz secr(ecbolic)
- ✳️Gallbladder: contraction
- ✳️Sphincter of Oddi: relaxation
Secretin Family: SECRETIN
endocrine
[H+] acid:✳️S-cells (SI)➡️rel SECRETIN
✳️Pancreatic Duct: secr HCO3
Hydrolatic-neutralize acid ⛔️FB Loop
Secretin Fam:GLP-1 + 2 (Incretins)
Endocrine¶crine
CHO/hyperosm soln:✳️L-cells (SI)➡️ rel GLP-1&2➡️
- ✳️Pancr B cells: secr INSULIN
- ✳️Stomach:⛔️gastric motility
- ✳️Intestine: ✅mucosal growth
Secretin Fam:GIP(Incretins)
Endocrine
CHO:✳️K-cells (SI)➡️ rel GIP:✳️Pancr cells➡️secr INSULIN
Somatostatin
Paracrine
PH<4/[H+] acid:✳️D-cells stomach ➡️rel SOMATO➡️
1.⛔️Parietal&Chief cell secr gastric acid/pepsin
2.⛔️G-cell Gastrin rel
3.⛔️ECL: Histamine rel
Histamine
Paracrine
Ach/Gastrin:✳️ECL cells stomach➡️rel. HISTAMINE:✳️Parietal cell HCl secr
Guanylin
Exocrine
Goblet cells: rel GUANYLIN➡️✳️LI CFPR➡️intestinal secr
Receptor e.coli toxin bound
cAMP&cGMP
VIP Agonist:R➡️✳️ AC/GC convert ATP➡️cAMP/cGMP:✳️PKA➡️ ✳️fl secretion ⬆️CFTR ⬇️NaCl abs
prolonged effect
Intracell [Ca2+] Mobilization
Ach agonist:R➡️ ⏫Ca2+➡️✳️PKC or Calmodulin➡️✳️ fl. secretion
⚡️short term
Prostaglandin tone
Submucosal paracrine rel from WBC & Fibroblast & Mast cell
✳️motility & fl.secretions
Excess sensitivity: ⏫fl secr➡️ diarrhea
Mastication fn
⬇️food size,
⬆️SA,
⬇️outer cellulose plants,
& mix with saliva
Inorgo non-rumen saliva
Hypotonic at low flow
⬆️Na/Cl/HCO3 & ⬇️K
Slightly acidic
