GI Flashcards
UC vs CD: Involves the rectum
UC
UC vs CD: Rectal sparing
CD
UC vs CD: Bimodal age of onset
UC
Ethinicity least affected by UC
Asians
Male to female ratio of UC and CD
Approximately equal
Effect of smoking on UC
May prevent disease
Effect of appendectomy on UC
Protective
UC vs CD: Pseudopolyps
UC
UC vs CD: Toxic megacolon
UC
Characteristic finding in UC described as villous atrophy and crypt regeneration with increased inflammation
Backwash ileitis
Criteria for IBS
Change in bowel habits lasting for 6 months without identifiable cause
Type of diarrhea seen in UC
Nocturnal
Important features of severe UC
1) Fever
2) Elevated ESR
3) Ulcerations
UC endoscopically described as fine granularity
Mild UC
UC endoscopically desrcibed as having coarse granularity with no ulcerations
Moderate UC
Complications of UC
1) Massive haemorrhage
2) Toxic megacolon
3) Perforation
4) Strictures
Segment of colon affected in toxic megacolon of UC
Transverse or right colon
Diameter of toxic megacolon
> 6cm
Most dangerous complication of UC
Perforation
Perforation in UC is most commonly due to
Megacolon
Finding in UC associated with HIV infection
Proctitis
T/F A colonic stricture is always presumed to be malignant unless proven otherwise
T
Type of polyps in UC that increases the risk for cancer
Post-inflammatory pseudopolyps
Extrainstestinal manifestations of UC
1) Erythema nodosum
2) Pyoderma gangrenosum
3) Ankylosing spondylitis
4) Anterior uveitis/iritis
5) Primary sclerosing cholangitis
UC vs CD: Abdominal mass
CD
UC vs CD: Fistulas
CD
UC vs CD: Response to antibiotics
CD
UC vs CD: Recurrence after surgery
CD
UC vs CD: ANCA-positive
UC
UC vs CD: Cobblestoning
CD
UC vs CD: Granuloma on biopsy
CD
UC vs CD: Entire GIT
CD
Highly selective marker for intestinal inflammation
Fecal lactoferrin
Earliest radiologic change in UC
Fine mucosal granularity
Ulcers seen in UC
Collar-button ulcers
UC vs CD: Increased pre sacral and perirectal fat
UC
Pharmacologic treatment for both CD and UC
Sulfasalazine
UC vs CD: Risk for colon CA
Both
Most common site of CD
Ileocecal area
UC vs CD: Skip leasions
CD
Earliest lesion seen in CD
Aphthous ulcer
Hallmark of CD
Focal transmural inflammatory process
Pathognomonic of CD
Creeping fat or fat wrapping
Histologic hallmark of CD
Noncaseating granuloma
Histologic feature that differentiates Tb from CD
Caseation
First line test for CD
CT enterography
Seen in radiograph of CD
String sign
UC vs CD: ASCA +
CD
T/F: Colon CA prophylaxis is an indication for surgery in CD
T
Surgery of choice for CD
Ileal pouch anal anastomosis (IPAA)
Most frequent complication of IPAA
Pouchitis
T/F Acute pancreatitis is reversible
T
Leading cause of acute pancreatitis
Gallstones
2nd most common cause of acute pancreatitis
Alcohol
Enzyme released in acute pancreatitis: Responsible for necrosis of fat
Lipase and phospholipase
Enzyme released in acute pancreatitis: Responsible for destruction of pancreatic parenchyma
Proteases
Enzyme released in acute pancreatitis: Responsible for destruction of blood vessels and subsequent interstitial hemorrhage
Elastase
Acute pancreatitis occurs in 5-20% of patients following this procedure
ERCP
Blue discoloration in the periumbilical region seen in acute pancreatitis
Cullen’s sign
T/F: Fever in acute pancreatitis is high grade
F
Lung finding in acute pancreatitis
Basilar rales
Cardinal symptom of acute pancreatitis
Abdominal pain
Basilar rales in acute pancreatitis is most commonly appreciated on which lung
Left
Blue-red-purple or green-brown discolouration of flanks seen in acute pancreatitis
Grey-Turner sign
Cullen’s sign is due to
Hemoperitoneum
Grey Turner sign is due to
Catabolism of hemoglobin
Acute necrotizing vs hemorrhagic pancreatitis: More severe
Acute necrotizing
Acute necrotizing vs hemorrhagic pancreatitis: Most severe
Hemorrhagic
Acute necrotizing vs hemorrhagic pancreatitis: Red-black hemorrhage and chalky fat necrosis
Acute necrotizing
Acute necrotizing vs hemorrhagic pancreatitis: Extensive parenchymal necrosis accompanied by dramatic hemorrhage within substance of gland
Hemorrhagic
Majority of islets of Langerhans are found on which part of the pancreas
Tail
Majority of pancreatic CA are found on which part of pancreas
Head
Insulinomas and glucagonomas are most frequently found on which part of the pancreas
Tail
Percentage of cells that must be destroyed to cause DM
> 70%
Earliest enzyme that elevates in acute pancreatitis
Amylase
Most specific enzyme for acute pancreatitis
Lipase
Amylase levels typically return to normal levels after ___ of acute pancreatitis
48-72h
Complications of chronic pancreatitis (2)
1) Pancreatic pseudocyts
2) Malabsorption
Endocrine vs exocrine pancreas: Destroyed in chronic pancreatitis
Both
Most common cause of chronic pancreatitis in adults
Long-term alcohol abuse
Most common cause of chronic pancreatitis in children
Cystic fibrosis
Diagnostic test for chronic pancreatitis with the best sensitivity and specificity
Secretin
Pancreatic grading: Normal pancreas
Grade A
Pancreatic grading: Focal or diffuse enlargement, irregular contour, in homogenous enhancement
Grade B