GI Flashcards
What are the criteria for diagnosis of irritable bowel syndrome?
At least three days of abdominal pain per month for at least three months, a change in the frequency of stool, improvement with defecation. IBS can be diagnosed by history and physical examination and routine lab testing as long as there are no warning signs.
How do you diagnose celiac sprue?
Serum IGA tissue transglutaminase (TTG)antibodies are highly sensitive and specific for celiac sprue. A small bowel biopsy showing villous atrophy is the gold standard for diagnosis.
What are the warning signs that would warrant further investigation beyond routine in a patient with possible irritable bowel syndrome?
Rectal bleeding, anemia, weight loss, fever, a family history of colon cancer, onset of symptoms after age 50, and a major change in symptoms.
Describe the features of and treatment for achalasia.
Involves the absence of peristaltic progression. Clinically it involves dysphagia of solids and liquids and increased risk of squamous cell carcinoma. Diagnosed by barium swallow or manometry. It is treated with long-acting nitrates, calcium channel blockers, pneumatic dilatation of the lower esophageal sphincter,.
Describe the features of and treatment for diffuse esophageal spasm.
It is a spastic motor disorder. Symptoms involve heartburn, chest pain or dysphagia which are often swallow induced. CAD should always be excluded. It is diagnosed with a barium swallow. Treatments include long-acting nitrates and calcium channel blockers.
What are the features of and management of scleroderma esophagus?
90% of patients with scleroderma have esophageal involvement. There may be no symptoms or there may be severe reflux, often with strictures or other motility abnormalities. It is diagnosed by barium swallow and manometry. It is treated with management of the reflux with H2-blockers and PPI’s and with prokinetic drugs.
Who should be screened for Barrett’s esophagus?
Patients who have heartburn symptoms for greater than five years or patients who need medication for heart burn symptoms for greater than five years. It may be reasonable to screen patients with multiple risk factors for Barrett’s esophagitis. These include male sex, Caucasian, age over 50, hiatal hernia, increasing BMI, and abdominal fat distribution.
What are the possible treatments for H. pylori infection?
B.i.d. for 7 to 14 days:
PPI, amoxicillin 1 g, clarithromycin 500 mg
All QID with PPI b.i.d. for 7 to 14 days:
Bismuth 525 mg, metronidazole 500 mg, tetracycline 500 mg
All b.i.d. for 14 days. These are rescue for prior treatments:
PPI, amoxicillin one gm metronidazole 500 mg
Also a rescue treatment:
PPI b.i.d. and amoxicillin TID for 14 days
PPI, levofloxacin 250 to 500 mg, amoxicillin 1 g
PPI, rifabutin 150 mg, amoxicillin 1 g
What is the treatment including duration for gastric versus duodenal ulcers?
A PPI or an H2 blocker, usually 4 to 6 weeks for duodenal ulcer and 12 weeks for a gastric ulcer. PPI’s lead to faster healing than H2-blockers.
What happens when a patient with GERD is treated for H. pylori infection?
The GERD may become worse because H pylori has a suppressive effect on acid secretion.
What drives are useful for inducing or maintaining my mission in patients with Crohn’s disease?
Budesonide is effective in inducing but not maintaining remission. Corticosteroids are more effective than placebo and 5-ASA products in inducing remission. Azathioprine and 6-MP are effective in inducing remission in patients with active disease. Methotrexate is i effective in inducing and maintaining remission.
What is the most common cause of infectious diarrhea in United States?
Rotavirus
What is the most common cause of bloody diarrhea in the United States?
Shigella
What is the treatment for Campylobacter diarrhea?
It is usually supportive care. It may be treated with erythromycin if it is culture proven. There is emerging fluoroquinolone resistance.
What is the treatment for E histolytica diarrhea?
Metronidazole