GI Flashcards
1
Q
H2RA
A
Cimetidine (Tagamet): competitive antagonist, reduces gastric acid secretion
Famotidine (Pepcid): Nizatidine: competitive antagonist, reduces gastric acid secretion
- long half-life
- few effects on CYP
- great potency
- rapid absorption, quick onset
YOU CAN FORM TACHYPHYLAXIS WITH H2RA
2
Q
Altercations with gastric acid secretion inhibitors
A
Risk of infection: acid is used to sterilize things in the stomach
Vitamin B12 deficiency: acid makes B12 into useable form
Decrease calcium: decrease in serum calcium levels
Decrease calcium absorption
Increase PTH
Increase osteoclasts
