GI Flashcards
amylase level greater than what is considered to be diagnostic of pancreatitis
1000u/l
can raised serum amylase levels diagnose pancreatitis
no but can suggest it as other things also raise it and in severe pancratitis serum amylase can be normal
sudden osnet abdo pain, vomitting profusely and pain in epigastric region that radiates to back , drank alot of alcohol
pancreatitis
symptoms of exacerbation of crohns
bloody bowel motions, fatigue, tachycardia, elevated inflammatory markers
chrons disease exacerbation and acutely unwell treatment?
IV hydration, electrolyte replacement and corticosteriods
macrocytic anaemia results from
increased utilisation of vitamin B12 by colonised bacteria
steatorrhoea is caused by
reduced conc. of conjugated bile acids
— can convert conjugated bile acids to unconjugated bile acids, which results in impaired micelle formation
bacteriodes
diarrhoe is due to
steatorrhea
Bacterial overgrowth syndrome constitutes a group of disorders characterised by
diarrhoea, steatorrhoea and macrocytic anaemia
anatomic stasis due to duodenal or jejunal diverticula can result in the development of
bacterial overgrowth syndrome
acquired deficiency of intrinsic factor is seen in
pernicious anaemia
pernicious anaemia does not have
diarrhoea or steatorrhoea
calcification of the pancreas
chronic pancreatitis
chronic pancreatic insufficiency is most commonly associated with chronic pancreatitis caused by
high alcohol intake or cystic fibrosis
Fish tapeworm infestation cause
vitamin b12 deficiency,but steatorrhoea, diarrhoea, jejuna diverticula make bacterial overgrowth syndrome more likely
history of HIV, white mass on lateral aspect of tongue which cannot be scraped off
oral hairy leukplakia
first line treatment for oral hairy leukoplakia
antivirals
oral hairy leukplakia
a non- premaliganant Epstein-barr virus manifestation
oral candiasis can typically be
scraped off with a tongue blade
white lacy patches
oral lichen planus
what deficincey is common in alcoholics
B1 (thiamine)
thiamine deficiency causes
Wernicke’e encephalopathy - confusion, coma, ataxia, nystagmus, with the preservation of pupillary responses
vitamin b3 deficiency (niacin) causes
pellagra characterised by diarrhoea, dermatitis and dementia
vitamin A deficiency causes
photophobia, dry conjunctiva, dry cornea, dry scaly skin, anaemia and growth retardation- it is essential for retinal pigments, epithelial maturation and bone development
Vitamin — deficincy may present in patients with alcholic cirrhosis
K
acute abdo pain, rapidly developing asictes, elevated liver enzymes, enlarged caudate lobe,
hepatous venous outflow obstruction or Budd Chairi syndrome
In Budd -chairi syndrome, venous thrombosis forms anywhere from the hepatic venules up to the entrance of the
Inferior vena cava
Most commonly in budd-chiari syndrome, the venous thrombosis is with the
hepatic vein
firts line diagnostic investigation for hepatic venous obstruction
Ultrasound doppler
Management steps for budd-chairi syndrome
initially- anticoagulation
secondly- angioplasty with/out stenting or thromlysis
third line- Transjugular intrahepatic portosystemic shunt ( TIPSS)
- liver transplant
treatment for Budd chairi syndrome , if AST >1000
liver transplantation
features of crohns disease
anorexia, fatigue, perianal and perioral ulceration, joint pain, rashes such as erythema nodosum
typically presents with bloody diarrhoea and mucus
ulcerative colitis
epigastric pain and heartburn symptoms
peptic ulcer disease
right upper quadrant pain and symptoms may be aggravated bu eating foods high in fat
gall stones
left iliac fossa abdominal pain - common in elderly
diverticulitis
corkscrew appearance on oesophagus
oesophageal spasm
barium swallow- post cricoid web , iron deficiency anaemia and dysphagia
Plummer vinson syndrome
spontaneous rupture of the oesophagus after forceful and severe vomitting. classically occur after excessive overeating and alcohol consumption. left sided pleural effusions is often an early finding on a CXR
boerhaave syndrome
bloody diarrhoea, tenesmus (feeling as though he needs to empty his bowels) and left lower quadrant tenderness point to
inflammatory bowel disease (Uc or crohns)
flu-like illness, anorexia, nausea and vomitting, general malaise followed by acute hepatitis with __ tenderness, jaundice pale stools and dark urine if cholestasis develops and on palpatation hepatomegaly will likely be present
= acute hepatitis A infection ]-common in north africa
RUQ
is there a significant risk of acute hepatitis A infection progressing to cirrhosis
NO!
HEP A and E transmitted by the
fAEcal -oral route
hep b and c by blood products and sexual intercourse and other ways
raised neutrophil count in ascites fluidin patient with cirrhosis of the liver and asictes
Spontaneous bacterial peritonitis
- serious complicatio and occur in approx 8% of cases of cirrhosis with ascites
- high mortality rate and high recurrence rate
most reflective of synthetic liver function
- pro-thrombin time and albumin
(pro-thrombin timw increases and is an indicator of acute sythetic function, albumin gives an indication of synthetic liver function over a longer period, given the half life 20 days in serum)
ALP would be raised in
cholestatic disease
ALT and AST represent liver
parenchymal function
hepatic portal vein is formed by the union of the
superior mesenteric and spenic veins
liver in patient is cirrhotic and and — vein is obstructed, this is the cause of caput medusae
hepatic portal
tropical sprue presents with
chronic dirarrhoea, weight loss, vitamin b12 and folate deficiencies- seen in tropical countires like india
predominant mononuclear cell infiltration and less villous atrophy throughout the intestine
tropical sprue
treatment of tropical sprue
broad spectrum antibiotics
presentation of somatostatinoma
gallstones, weight loss, diarrhoea and diabetes mellitus
Glucagonoma typically presents with
diabetes mellitus, weight loss, anaemia, and classical rash is necrolytic migratory erythema
insulinoma presents with
sweating, weight gain, light-headedness and loss of consciousness- exacerbated by exercise or fasting
gastrinoma characterised by
peptic ulceration, gastric acid hypersecretion, non B cell islet tumour of the pancreas
VIPoma presents with
severe watery diarrhoea, which therefore gives significant hypokalemia, and achlorhydria
abdo pain which radiates to the back, significant elevation in amylase levels following endoscopic retrograde cholangiopancreatography (ERCP)
Post ERCP pancreatitis
vomitted bright red blood twice, palpable spleen tip, spider naevi over the check neck and arms
oesophageal varices
spleonmegaly and spider narvi are suggestive of
chronic liver failure with portal hypertension
immediate management of oesophageal varices
resuscitation, PPI, urgent endoscopy to diagnose and treat teh source of bleeding
Mallory-weiss tear classicaly occurs after severe
retching and vomitting or coughing
red flags for malignancy
appetite and anaemia
red flags for malignancy and luminal obstruction what investigation
colonoscopy
most common causes of exudative ascites are
infection or malignancy
causes of transudative ascites
-cardiac failure, portal hypertension, fulminant hepatic failure, budd-chairi syndrome
relatively common in elderly, muscle and joint pain, fatigue, red dots on the skin (perifollicular heamorrhages), bleeding and inflammation of the gums (gingivitis) ,easy brusing
scurvy (VITAMI C DEFICIENCY)
hypothyroidism is more likely to do what to weight
weight gain
and dry, coarse skin
lead posioning
abdo pain, confusion, headaches
while vitamin K deficiency may cause bleeding and easy brusing, it is much less common than
vitamin C defiency
you would expect a raised plasma urea level in
gastric ulcer
urea is produced as a by-product from the digestion of
blood
epigastric pain, which ususally occurs before meals or at night, relieved by eating or drinking milk
duodenal ulcer
duodenal ulcers usually occur in the presence of oversecretion of gastric acid
causes of duodenal ulcer:
HELICOBACTER PYLORI,NSAIDS, STERIODS AND ASPIRIN
GASTRIC ULCERS ARE LESS COMMON THAN DUODENAL ULCERS AND PATIETNS WITH GASTRIC ULCERS TEND TO HAVE
NORMAL OR LOW SECRETION OF GASTRIC ACID
solitary, well defined painful lesion in mouth
aphthous ulcer - benign oral lesion found in approx 20% of the population
- common triggers coffee and chocolate
first line management of aphthous ulcer
topical steriods and topical lidocaine for pain control
shaggy, white patch on the lateral aspect of the tongue
oral hairy leukoplakia
oral steriods should eb used cautiously in patietns with daiebets as they can cause
hyperglycaemia
treatment for oesophageal varices in patient with known alcoholic liver disease
non-specific beta blockers- nadolol and propanolol
blood and tender iliac fossa hint
UC
Ulcerative colitis is strongly associated with
primary sclerosing cholangitis
UC raised
ALP, ASMA, isolated ALP is often observed
what reduces surface mucus secretion
Aspirin
taking aspirin with — has been shown to reduce the risk of GI bleeding and peptic ulceration
PPI
aspirin causes increased acid production from gastric parietal cells as — normally inhibit acid secretion
prostaglandins
first line treatment for Hep C
Direct acting antivirals
diarrhoea, wheezing, flushing, weight loss
Neuroendocrine tumour