German - Immune Memory And Vaccination Flashcards
T/F - Ab’s developed during the primary response provides protective immunity.
TRUE
- New adaptive immune response is not activated
- Serum Ab levels decline w/ time
What are 3 adaptive memory cells?
Memory B cells
Memory plasma cells
Memory T cells
- Central
- Effector
Where do memory cells develop?
Secondary lymphoid tissue
-Mirror pathogen-specific effector cells
—Th17 CD4 memory T cells
Where do memory cells persist?
Bone marrow
Secondary lymphoid tissues
Peripheral tissue
Circulation
How do primary effector cells differ from memory cells?
Primary -BROAD antigen response -Multiple activation steps and signals -Clonal selection and expansion must occur -B cells must undergo target refinement —Somatic hypermutation —Class switching -Cannot undergo somatic hypermutation again -Die after several days
Memory -SPECIFIC, restricted antigen response -Easily activated -Clonal expansion -B cell target refinement unnecessary -May undergo somatic hypermutation -Persist for months and replicate —LT immunity
T/F - Immune memory can persist for decades.
TRUE
T/F - Immune memory is pathogen and exposure dependent.
TRUE
T/F - Immune memory does NOT depend upon antigen persistence.
TRUE
- Steady-state serum Ab levels
- Persistence is highly variable across diseases
The secondary immune response activates _________ B cells and inhibits _________ B cells.
Memory
Naive
Tell me about the primary response.
Naive B cell binds pathogen
Naive B cell is activated and becomes an ab-producing plasma cell
Production of low-affinity IgM Ab’s
Tell me about the secondary response.
Naive B cell binds pathogen coated with specific antibody
A negative signal is given to the naive B cell to prevent its activation
*No production of low-affinity IgM Ab’s
OR
Memory B cell binds pathogen
Memory B cell is activated and becomes an Ab-producing plasma cell
Production of high-affinity IgG
T/F - Memory B cells improve with repeated exposure.
TRUE
T/F - Activated memory B cells replicate into plasma cells and more memory cells.
TRUE
*This is the whole point behind vaccine “boosters”
T/F - Memory B cells can form cognate pairs w/ memory Tfh cells.
TRUE
- Germinal centers
- Class switching
- Somatic hypermutation
T/F - Memory T cells do not req CD28 co-stimulation.
TRUE
