geriatric

Question 1

how much do older adults body water % decrease by and how does it affect distribution?

Answer 1

10-15% decrease- decreases VD for water soluble drugs and has a higher peak for plasma concentrations

Question 2

why is volume of distribution increased in older adults with fat soluble drugs?

Answer 2

muscle wasting and fat cells increase by 40% which increases lipophilic drugs half-life leading to drug accumulation

Question 3

at what age does GFR steadily start to decrease?

Answer 3

age 40 there is a 10% decrease per decade

Question 4

Is albumin increased or decreased with age and how does it affect drug concentration?

Answer 4

decreased- protein bound drugs are increased in concentration and increases free drug

Question 5

How does aging affect phase 1 and phase 2 metabolism?

Answer 5

Phase 1 metabolism is slowed, phase 1 is not affected

Question 6

Which PK is most affected by aging?

Answer 6

excretion/elimination

Question 7

What receptors are decreased with aging?

Answer 7

baroreceptors response to blood pressure

Question 8

_______ responsiveness to antipsychotics with aging due to depletion of dopamine

Answer 8

increased

Question 9

Why is there an increase in CNS toxicity to fluoroquinolones in aging?

Answer 9

impaired renal function

Question 10

Why is there a reduced response to diuretics with aging?

Answer 10

decline in GFR and impaired adaptive mechanisms