Genetics - Ch. 13 Flashcards
3 main genetic mutation types that cause WBC cancer
- Pro-growth arrested differentiation (MYC, RTK)
- Txn factor increased self-renewal (MLL, PML-RARA)
- Decreased apoptosis (BCL2)
NOTCH1
T-ALL or worse prognosis of CLL
t(12;21) RUNX1-ETV6
B-ALL
TdT
Pre-B and Pre-T lymphoblasts (ALL)
CD1-8
Exception?
T cells (CD5 is some B cells)
t(9;22) BCR-ABL
B-ALL, CML
Deletions of 13q, 11q, 17p
CLL/SLL
BTK activation via kinase cascade
CLL/SLL
CD19, CD20
B cells (Pre-B, mature B- NOT plasma cells)
t(14;18) BCL2 overexpression
- Follicular lymphoma
- DLBCL (from FL)
MLL2 histone methyltransferase mutation
Follicular lymphoma
BCL6 dysregulation
Diffuse large B-cell lymphoma
KSHV/HHV-8 infection
Primary effusion lymphoma (DLBCL subtype)
Translocation w/ chromosome 8 – t(8;14) usually
Burkitt lymphoma (Chromosome 8 = MYC gene, Chromosome 14 = Ig locus)
High cyclin D1, CD19, CD20, IgM and IgD w/ light chains, CD5+, CD23-
Mantle cell lymphoma
Monoclonal IgM secretion, MYD88 mutation, CD20+
Lymphoplasmacytic lymphoma