Cell Cycle Nonspecific Drug Tables - Fitz

Question 1

Dacarbazine, Procarbazine, Temozolomide - function

Answer 1

Methylate guanosine at O6, N7 - causing DNA miscoding and damage

Question 2

Dacarbazine use

Answer 2

Metastatic melanoma

Question 3

Procarbazine use

Answer 3

Malignant glioma

Question 4

Temozolomide uses

Answer 4

Resistant glioma, astrocytoma

Question 5

Carmustine, Lomustine - function

Answer 5

Alkylate guanosine at O6, N7 - causing DNA miscoding and damage

Question 6

Carmustine, Lomustine - uses

Answer 6

Brain tumors, lymphoma, melanoma

Question 7

Streptozocin function

Answer 7

Beta cell islet destruction

Question 8

Streptozocin use

Answer 8

Insulinoma

Question 9

Streptozocin toxicity

Answer 9

Diabetes

Question 10

Cyclophosphamide, Ifosfamide - function

Answer 10

Crosslinks DNA

Question 11

Mechlorethamine use

Answer 11

MOPP regimen (lymphoma)

Question 12

Melphalan use

Answer 12

Multiple myeloma

Question 13

Chlorambucil use

Answer 13

CLL

Question 14

Busulfan use

Answer 14

CML

Question 15

Melphalan, Chlorambucil, Busulfan - function

Answer 15

Crosslinks DNA

Question 16

Thiotepa, Mitomycin C, Altretamine - function

Answer 16

DNA G-G crosslinks

Question 17

Thiotepa uses

Answer 17

Breast, ovarian, bladder

Question 18

Mitomycin C uses

Answer 18

Breast, GI

Question 19

Altretamine use

Answer 19

Recurrent/resistant ovarian

Question 20

Cisplatin, Carboplatin, Oxaloplatin - function

Answer 20

Platinum-Cl conversion to Platinum-H2O, which disrupts DNA

Question 21

Cisplatan uses

Answer 21

Testicular (w/ bleomycin, vinblastine/etoposide), ovarian, NSCLC

Question 22

Carboplatin use

Answer 22

Ovarian

Question 23

Oxaloplatin

Answer 23

Colorectal (FOLFOX regimen)

Question 24

Cisplatin toxicities

Answer 24

Renal disease, ototoxicity, N/V

Question 25

Carboplatin toxicity

Answer 25

Neutropenia

Question 26

Oxaloplatin toxicities

Answer 26

Neutropenia, cold-induced neuropathy