Cell Cycle Nonspecific Drug Tables - Fitz Flashcards
1
Q
Dacarbazine, Procarbazine, Temozolomide - function
A
Methylate guanosine at O6, N7 - causing DNA miscoding and damage
2
Q
Dacarbazine use
A
Metastatic melanoma
3
Q
Procarbazine use
A
Malignant glioma
4
Q
Temozolomide uses
A
Resistant glioma, astrocytoma
5
Q
Carmustine, Lomustine - function
A
Alkylate guanosine at O6, N7 - causing DNA miscoding and damage
6
Q
Carmustine, Lomustine - uses
A
Brain tumors, lymphoma, melanoma
7
Q
Streptozocin function
A
Beta cell islet destruction
8
Q
Streptozocin use
A
Insulinoma
9
Q
Streptozocin toxicity
A
Diabetes
10
Q
Cyclophosphamide, Ifosfamide - function
A
Crosslinks DNA
11
Q
Mechlorethamine use
A
MOPP regimen (lymphoma)
12
Q
Melphalan use
A
Multiple myeloma
13
Q
Chlorambucil use
A
CLL
14
Q
Busulfan use
A
CML
15
Q
Melphalan, Chlorambucil, Busulfan - function
A
Crosslinks DNA
