Genetics and Random Facts

Question 1

CK1ε

Answer 1

Binding region of the hPer2 gene associated with advanced sleep-wake phase disorder.

Question 2

hPer2 Gene

Answer 2

Genetic mutation associated with advanced sleep-wake phase disorder (ASWPD).

This mutation leads to hypophosphorylation of the period protein by CK1ε

Question 3

PHOX2B gene

Answer 3

Associated with congenital central alveolar hypoventilation syndrome.

Question 4

DQB1*0602

Answer 4

Narcolepsy type 1 (narcolepsy with cataplexy) is associated with this HLA subtype.