Genetics and Prematurity Flashcards
How many births are preterm?
1 in 8
What are 8 major influences that influence preterm birth?
genes,fetal growth, gestational clock, uterine activity, labor cascade, membrane strength, susceptibility to infection and twinning
In 3rd week, what is developed?
neural tube
In 4th week, what is developed?
heart beat
In 7th week what is developed?
a rudimentary skeleton
In 7th - 8th week, what is developed?
sexual development
______ is any agent that can harm an embryo or fetus
teratogen
True or False, one teratogen can cause different defects
TRUE
What are some rule-of-thumbs relatated to teratogens
longer exposire/higher dose = more harm, father’s exposure may affect embryo, lon-term effects depend on postnatal environemnt, some effect not apparent until later in life
What 2 things make each pregnancy unique?
genetic makeup and prenatal environment
3 things that affect perinatal environment
medications, delivery practices, and social environment
7 problems you might expect to see in premature infants
poor thermal regulation, immature CNS, immature immunity, IVH, immature cardiopulmonary system, immature GI system, an dGLucose instability
Nursing interventions for poor thermal regulation premies
prewarming the delivery room and placing infant in a plastic bag up to the neck during delivery room stabilization to prevent heat loss
What is apnea?
pause in breathing of longer than 10 to 15 seconds assoc. with bradycardia, cyanosis or both
Your are caring for a premie baby in the NICU. The alarm for desats goes off. What are your actions?
Assess baby for signs of breathing and skin color. If apneic, cyanotic or bradycardic, tactile stimulation needs to be given. If that doesn?t work, bag and mask w/ suctioning and airway positioning
What does IVH stand for?
Intraventricular Hemorrhage
What are risk factors for IVH?
extreme prematurity, presence of labor, birth asphyxia and need for vigorous resuscitation, mechanical ventilation, sudden change in BPs r/t hypetonic volume expansion
Describe common s/s for IVH
symptoms of increased intracranial presure- seizures, decreased or absent reflexes, hypotonia, bulging fontanels, enlarged head circumference, setting-sun eyes, shrill cry, hypothermia, apnea and bradycardia
________ is a hypoxic-ishemia injury to the mucosa of the intestinal tract which results in abdominal distention, sepsis, and nutritional impairment
Necrotizing enterocolitis
_____ ______ is causes vessel damage in the tiny periventricular capillaries, resulting in symptoms on increase ICP
Intraventricular Hemorrhage
NEC, is the disease of prematurity. What are the parameters for prematurity?
< 1000 grams, <28 weeks gestation
NEC is associated with what other interrelationships?
ishemia, immunity, infection, immaturity, nutrition
What is the grading system for IVH?
grade 1 = small bleed, grade 2= severe bleed
You are caring for a baby with NEC, how are you going to proceed with feeding?
constant 1-2 ml per hour flow, and mom’s milk b/c fortified with antibodies
Soft signs ( hard to identify) in NEC, include-
increased residual, lethargy, blood glucose instability, and temp instability
S/s of NEC include:
abdominal distention, visible bowel loops, bloody stool, feeding intolerance, bilious vomiting, apnea, bradycardia, desat
A baby was just admitted for NEC, what are your first actions?
stop all feedings and place IV for fluids. 100-120cc/kg/day
What are nursing management goals for NEC?
ventilation by trach, NG compression and TPN, broad spectrum antibiotics, pain control and minimal handling, serial exams and abd. Xrays, grequent labs, surgery
clef lip > in _____, palate > in _____
boys, girls
What ages are lip and palate correction surgeries performed?
lip - 2 week - 3 mon, palate 6-18 mon (minimize speech impairment)