Genetics 2 Flashcards
Method of becoming aneuploid where chromatids stay together
Nondisjunction
Method of becoming aneuploid where one chromatid gets left behind in cytoplasm and is lost
Anaphase lag
Mosaicism is common in sex or autosomal chromosomes?
Sex chromosomes
two or more cell populations with different chromosome complements in a single organism
Mosaicism
Inversion that does not involve centromere
Paracentric
Inversion that involves centromere (involves both arms, p and q)
Pericentric
Describes a deletion where two breaks in chromosome arm with intervening material lost
Interstitial
Describes a deletion where one break in arm with loss of chromosome end
Terminal
two chromosome breaks and intervening material is inverted and reincorporated into chromosome
Inversion
one arm is lost and remaining arm is duplicated; resulting chromosome has two short or two long arms
Isochromosome
rearrangements involving 2 or more nonhomologous chromosomes
Translocation
Type of translocation involving Two acrocentric chromosomes (really short small arms)
Long arms fuse at centromere and Short arms are lost
Parent may be normal phenotype but pass disease on to children
Robertsonian translocation
Genetics lab technique:
DNA pol runs in presence of differentially labeled nucleotides
Analyzing the length of the copies and the type of label of each allows construction of the sequence
Sanger sequencing
Genetics lab technique: similar to Sanger but is massively parallel, millions of fragments are sequenced per run
Next generation sequencing
Genetics lab technique: identifies variations in length of amplified segment
E.g. used to detect Fragile X syndrome
Amplicon length analysis