Genetics

Question 1

Each gene variant makes quite small contribution
and can be ______ by the environment

Answer 1

modified

Question 2

According to the liability/threshold model, all of
the factors which influence the development of
a multifactorial disorder

Answer 2

, whether genetic or environmental, can be considered as a single
entity known as liability. The liabilities of all individuals in a population
form a continuous variable, which can be
exemplified by a bell shaped curve.

Question 3

Factors that increases recurrence risk

Answer 3

Number of affected family members
Frequency of condition in the population

Question 4

Advantages of personalised medicine when dealing with genetics varients

Answer 4

Prevention: early detection of patients at risk, improve preventive measures
Diagnosis: accurate disease diagnosis enabling individulized treatment
Treatment: improved outcomes through targeted treatments and reduced side effects.

Question 5

Polygenic risk scores:

Answer 5

A statistically calculated score taking into account large numbers of variants that have been associated with a condition. Useful for stratifying risk within a population for intervention