Genetic stuff

Question 1

novel property mutation example and definition

Answer 1

sickle cell trait

AA change make new property without changing function of protein

Question 2

hardy weinberg equation

Answer 2

(p+q)^2=P^2+2pq+q^2

Question 3

what is p^2 in hardy weinberg

Answer 3

frequency of homo dominant

Question 4

what is q^2 in hardy weinberg

Answer 4

frequency of homo recessive

Question 5

what is 2pq in hardy weinberg

Answer 5

frequency of heterozygote

Question 6

what are p and q respectively in hardy weinberg

Answer 6

p is frequency of dominant allele and q is frequency of recessive allele

Question 7

what is q generally equal to in population genetics?

Answer 7

the square root of prevalence of autosomal recessive disease

Question 8

what do we assume p to be about equal to in population genetics?

Answer 8

p=1

Question 9

what does the risk of being a carrier in the population usually equal?

Answer 9

square root of prevalence times two

because q is equal to square root of prevalence and p is equal to 1 and the overall risk is equal to 2pq

Question 10

definition of founder effect in genetics

Answer 10

non random distribution of alleles in a population because small number of founding individuals

Question 11

factor V lieden genetic inheritance pattern, risk and unique aspect

Answer 11

autosomal dominant

increases risk of thrombosis..DVT

incomplete penetrance

Question 12

definition of haploinsufficiency

Answer 12

normal physiology requires more than 50% of gene product so with one mutated allele you see effects

Question 13

dominant negative effect definition

Answer 13

abnormal protein interferes with the normal protein being made