Genetic- Predisposition to adult onset disease Flashcards
What is an advantage of predictive testing?
Uncertainty of gene status removed.
What is the advantage of a negative predictive test?
Concerns about self and offspring reduced.
What is the advantage of a knowing positive predictive test?
- make plans for the future
- arrange surveillance/treatment if any
- inform children/decide whether to have children.
What are the possible disadvantages of predictive testing if positive?
- removes hope
- continues uncertainty (when)
- known risk to offspring
- impact on self / partner / family / friends
- potential problems with insurance / mortgage.
What are the possible disadvantages of predictive testing if negative?
- expectations of a ‘good’ result
- ‘survivor’ guilt.
What does predictive testing require?
- Information used for prevention/treatment
- Proper counselling- risk, implications
- Adequate information on the level of uncertainty
When is predictive testing easy?
Single gene disorder with high penetrance
When is predictive testing more difficult?
Polygenic gene disorder interacting with environmental factors
When is predictive testing done in children or adults?
Done when there are potential medical benefits
Who doesn’t have access to the information from genetic testing?
Third parties (insurers)
