GENETIC EXPLANATIONS OF OCD

Question 1

Name 3 genes implicated in the development of OCD?

Answer 1

1. SERT Gene
2. PTRPD & SLITRK3 Gene
3. DRD4 Gene

Question 2

SERT GENE?

Answer 2

• Gene which codes for the reuptake of serotonin in the synaptic cleft.
• Variations in this gene is linked to reductions in serotonin levels (which may cause heightened anxiety and development OCD symptoms)

Question 3

PTRPD and SLITRK3 genes ?

Answer 3

• Involved in neural development and plays a role in synapse formation
• Variations in PTRPD linked to neurodevelopmental disorders and OCD
• Variations in SLITRK3 gene is linked to overactive brain circuits seen in OCD

Question 4

DRD4 gene?

Answer 4

• Gene codes for dopamine receptor D4.
• Certain variations in DRDR have been linked to risk-taking, impulsivity, and OCD

(Due to dysregulations in dopamine pathways)