Generalities Flashcards
Mitotic division: Prokaryotes or Eukaryotes?
Eukaryotes
DNA within a nuclear membrane: Prokaryotes or Eukaryotes?
Eukaryotes
DNA associated with histones: Prokaryotes or Eukaryotes?
Eukaryotes
Chromosome number of Prokaryotes
One
Chromosome number of Eukaryotes
More than one
Membrane-bound organelles: Prokaryotes or Eukaryotes?
Eukaryotes
Size of Ribosome of Prokaryotes
30s 50s (70s)
Size of Ribosome of Eukaryotes
40s 60s (80s)
Cell wall containing Peptidoglycan: Prokaryotes or Eukaryotes?
Prokaryotes
Noncellular pathogens that can only reproduce when present within a living cell
Virus
Basic unit of life
Cell
Obligate intracellular but acellular parasites of plants with naked RNA; Do not cause human diseases
Viroids
Mobile genetic elements
Transposons
DNA pieces that move readily from 1 site to another either within or between the DNA of bacteria, plasmids and bacteriophages
Jumping genes
DNA replication followed by insertion of new copy into another site
Replicative Transposition
DNA is excised from the site without replicating and then inserted into the new site
Direct Transposition
Infectious proteinaceous agents with high beta-sheath content; Expressed in neurons
Prions
Susceptible to protease; Soluble in detergent
PrPc
Appearance of the vacuolated neurons with loss of function and lack of an immune response or inflammation; With prion proteins inside
Spongiform Encephalopathies
Approximate diameter: Viruses
0.02-0.2 um (under electron microscope only)
Approximate diameter: Bacteria
1-5 um
Approximate diameter: Fungi
3-10 um (yeasts)
Approximate diameter: Protozoa and Helminths
15-25 um (trophozoites)
Nucleic Acid: Viruses
Either DNA OR RNA
Nucleic Acid: Bacteria, Fungi, Protozoa, Helminths
Both DNA AND RNA
Type of Nucleus: Viruses
None
Type of Nucleus: Bacteria
Prokaryotic
Type of Nucleus: Fungi, Protozoa, Helminths
Eukaryotic
Ribosomes: Fungi, Protozoa, Helminths
80s (40s 60s)
Ribosomes: Viruses
Absent
Ribosomes: Bacteria
70s (30s 50s)
Mitochondria: Fungi, Protozoa, Helminths
Present
Mitochondria: Viruses, Bacteria
Absent (metabolic enzyme of bacteria: in the cytoplasm)
Nature of outer surface: Viruses
Protein capsid and Lipoprotein envelope
Nature of outer surface: Bacteria
Rigid wall containing Peptidoglycan
Nature of outer surface: Fungi
Rigid wall containing Chitin (cell wall)
Nature of outer surface: Protozoa and Helminths
Flexible membrane (Cholesterol - lipid bilayer)
Motility: Viruses
None
Motility: Bacteria
Some (those with flagella)
Motility: Fungi
None
Motility: Protozoa and Helminths
Most
Method of Replication: Viruses
Not binary fission
Method of Replication: Bacteria
Binary Fission
Method of Replication: Fungi
Budding or Mitosis2
Method of Replication: Protozoa and Helminths
Mitosis3
Only vertebrate flagellated cell
Sperm
Human Prion Disease: Present with higher cortical function impairment; Sensorial changes, loss of cognition
Creutzfeldt-Jakob Disease
Human Prion Disease: Present with cerebellar function impairment; Loss of correlation
Kuru Disease
Animal Prion Disease of sheep and goats
Scrapie
Most common Animal Prion Disease
Bovine Spongiform Encephalopathy (BSE) or Mad cow Disease
Animal Prion Disease of mule, deer, elk
Chronic Wasting Disease
Pathogenesis of Prion Diseases
Very long incubation periods, as long as 30 years
Transmission of Prion Diseases
Via infected tissue, cuts in skin; transplantation of contaminated tissues (cornea); use of contaminated medical devices (brain electrodes); ingestion of infected tissue (cannibalism); via inherited syndrome
Spectrum of Disease: Prion Diseases
Progressive neurodegenerative disease: loss of muscle control, shivering, myoclonic jerks and tremors, loss of coordination, rapidly progressive dementia, death
Treatment of Prion Diseases
No treatment available
Same amino acid sequence
Isomers
Proteins with same amino acid sequence but different folding patterns
Conformers
Bacterial shape: Spheres
Cocci
Bacterial shape: Rods
Bacilli
Bacterial shape: Spirals
Spirochetes
Bacterial shape: Spherical rods
Coccobacilli
Pattern of Cocci: Pairs
Diplococci
Pattern of Cocci: Chains
Streptococci