General Pharmacology Flashcards
1
Q
Bioavailability
A
% of administered drug that reaches systemic circ. as intact drug
2
Q
Factors Affecting Distribution
A
- Size
- Lipophilicity
- Ionisation
- Plasma Protein Binding
3
Q
Volume of Distribution = …
A
Dose of drug / Measured Conc.
4
Q
Biggest Determinant of Drug Distribution
A
Volume of Distribution (Vd)
5
Q
Liver Metabolism Phase 1
A
- Catabolic (ox, red., hydrolysis)
- CYP450 enzymes
- Reactive group added (Functionalisation)
- Increased Polarity
6
Q
Liver Metabolism Phase 2
A
- Anabolic & involves Conjugation (added elements)
- Results in Inactive Products
7
Q
Elimination - First Order Kinetics
A
- Elimination depends on conc.of drug
- Enzymes = Unsaturated
8
Q
Elimination - Zero Order Kinetics
A
- Same rate of elim. independent of plasma protein
- Enzymes = saturated
