ANS Pharmacology

Question 1

Receptors in ANS

Answer 1

[N] = Nicotinic ACh Receptor
[M] = Muscarinic ACh Receptor
[a] = Norepinephrine receptor subtype
[b] = Norepinephrine receptor subtype

Question 2

Distribution of Major Receptors in ANS Part 1

Answer 2

Question 3

Distribution of Major Receptors in ANS Part 2

Answer 3

Question 4

Muscarinic Agonists - Acetylcholinesterase Inhibitors

Answer 4

• Inhibit breakdown of ACh
• Increases effect of ACh on Muscarinic receptors
• E.g Pyridostigmine

Question 5

Muscarinic Antagonists

Answer 5

• Prevent Muscarinic Receptors from ACh
  E.g:
• Atropine
• Hyoscine
• Ipratropium

Question 6

Alpha-1 Adrenoreceptor Agonists

Answer 6

• Used as nasal decongestant
• used w LA -> prolong action
  E.g:
• Methoxamine
• Phenylephrine

Question 7

Alpha-2 Adrenoreceptor Agonists

Answer 7

• Activate Inhib. neurons in CNS -> Decreased Noradrenaline -> Oppose SNS
  E.g:
• Clonidine
• Methyl-dopa

Question 8

Alpha-1 Adrenoreceptor Anatgonists

Answer 8

• Affects Bladder
  E.g:
• Tamsulosin
• Prazosin

Question 9

Alpha-2 Adreoreceptor Antagonists

Answer 9

• Increase Noradrenaline -> increased SNS response
  E.g:
• Phentolamine

Question 10

Beta-1 Adrenoreceptor Agonists

Answer 10

• Affects Heart
  E.g:
• Dobutamine

Question 11

Beta-2 Adrenoreceptor Agonists

Answer 11

• Affects Lungs
  E.g:
• Salbutamol

Question 12

Beta Antagonists

Answer 12

Cardioselective:
- Atenolol
- Metoprolol
- Nebivolol
Non-Cardioselective
- Propanolol
- Carvediolol