General facts 2 Flashcards
What three metabolites are absorbed at the tip of a villus along with Na?
glucose
amino acids
Cl
What are the 4 mechanisms of diarrhoea?
altered epithelial cell transport
altered structure and permeability
osmotic effect
altered motility
What is the general term for the toxins produced by E.coli and Vibrio cholerae which cause secretory diarrhoea?
enterotoxin
Which E.coli toxin interferes with adenyl cyclase?
heat labile toxin
Which E.coli toxin interferes with guanyl cyclase?
heat stable toxin
Can glucose still be absorbed into epithelial cells in the presence of enterotoxins e.g. heat labile toxin?
yes
Why does a villus become more secretory when Salmonella infects epithelial cells?
there is a faster rate of turnover of crypt cells leading to more immature cells at the tip which are more secretory
What can inflammation do to the gut vasculature?
it can increase its permeability
What is dysentery?
the presence of blood and mucosal shreds in watery faeces
What is an example of a pathogen which causes osmotic diarrhoea?
Cryptosporidium
What is the term for hypomotility of the gut?
ileus
What may be a cause of hypomotility of the gut?
bacterial multiplication in the intestines
What leads to increased gut motility in TGE?
prostaglandins involved in inflammation
What is a problem relating to small intestinal disease which can be caused due to malabsorption and maldigestion of nutrients and increased bowel permeability?
hypoalbuminaemia
What heart problem can be associated with diarrhoea and why?
cardiac arrhythmia because of potassium depletion in severe diarrhoea
What is the main cause of septicaemic colibacillosis in lambs and foals?
absence of circulating antibodies because very young animals have not fed on colostrum
Piglets and calves at what age are most susceptible to enteric colibacillosis?
3-10 days
Is inflammation a big part of enteric colibacillosis?
no
What is the name of the pathogenicity island EHEC and EPEC need for virulence?
LEE= locus for enterocyte effacement
What toxin does EHEC produce and what does this do?
Shiga like toxin, inactivates 60s ribosome subunit
What two parts of the body does EHEC infect when it becomes systemic?
kidney
brain
Do most animals infected with EHEC show disease?
no
What can EHEC cause in humans?
Haemolytic uraemic syndrome
At what temperature is EHEC killed?
60 degrees
In what two conditions does EHEC multiply in pigs?
stress
changes in diet
What are the adhesins used by UPEC?
P pili
What are 4 groups of animals which asymptomatically carry Campylobacter spp?
domestic species
lifestock
poultry
wildlife
What is the optimum growth temperature of Campylobacter?
37-42 degrees
Where is the highest number of Campylobacter in chickens?
caecum
What might prevent Campylobacter invading chicken epithelial cells?
chicken mucus
At what age do most chicks become infected with Campylobacter?
10-14 days
What two things can induce carrier, non-shedder birds to become shedders?
stress
change of diet
What 4 species of Campylobacter do dogs carry?
jejuni
coli
upsaliensis
hypointestinalis
In what 3 situations can antimicrobial treatment be used to treat Campylobacter infections in dogs?
immunocompromised patients
severe clinical signs
extra-intestinal signs
What 4 squamates are most commonly carriers and shedders of Campylobacter?
bearded dragons
green iguana
western beaked geko
blotched blue-tongue skink
In what management are cattle higher carriers of Campylobacter?
feedlot (cattles fed in yards)
What disease can Campylobacter cause in pigs?
colitis
What species of Campylobacter do pigs most commonly carry?
jejuni
coli
What are three causes of Campylobacter induced colitis in pigs?
poor hygiene
wet floor surfaces
secondary infection
What bacteria is associated with proliferative enteritis in pigs?
Campylobacter hypointestinalis
What is the morphology of most Campylobacter bacteria?
spiral
What medium should be used to transport Campylobacter?
Cary-Blair
Where is Campylobacter found in eggs?
on the surface
What is the term for processing Campylobacter positive and negative chickens through separate processes?
logistic slaughter
What precaution during chicken rearing could be taken to reduce spread of Campylobacter to humans?
no thinning
What is a technique for serological identification of Salmonella?
slide agglutination test
What antigen is usually used to classify Salmonella?
O antigen
What is the name of the apparatus Salmonella uses to invade epithelial cells?
Type Three Secretion System (TTSS)
Is enteric inflammation part of Salmonellosis?
yes
What can gut perforation caused by Salmonella induced necrotic enteritis lead to?
peritonitis
What are the three forms of enteritis Salmonella can cause?
haemorrhagic enteritis
necrotic enteritis
acute fibrinous enteritis
What four places does Salmonella often reside in?
liver
spleen
lymph nodes
bone marrow
What does Salmonella cause the formation of in extraintestinal sites of infection?
granulomas
What is the term to describe bacteria escaping to new foci?
dispersive infection
What disease is caused by Salmonella Gallinarum and what species is this in?
Fowl typhoid, birds
In what two ways can S. Gallinarum be passed between birds?
egg transmission
faecal oral route
What are two diseases which can be caused by Salmonella in birds?
Pullorum disease
Fowl typhoid
What age are the birds which show disease after Salmonella Gallinarium infection?
adults
What is the two names for the disease caused in birds by Salmonella which is usually transmitted via eggs and affects young birds?
Pullorum
Bacillary white diarrhoea
What 4 organs can be particularly infected in septicaemic salmonellosis?
lungs
kidney
pericardium
joints
What condition affecting the joints can be caused by salmonella?
acute septic arthritis
What food borne salmonella species is associated primarily with cattle?
Salmonella Typhimurium
Why is the bacteria causing food borne Salmonella in humans particularly bad?
because it is multi-drug resistant
What must Salmonella infect in a bird for it to contaminate eggs?
ovaries
What does the Salmonella vaccine in chickens vaccinate against?
Salmonella Enteritidis
Where is the flagella found in a Brachyspira bacteria?
between the inner and outer membrane
What age of pigs does swine dysentery usually effect?
8-14 week old piglets
To what region of the gut is swine dysentery confined?
large intestine
What 6 pathologies can Brachyspira hyodysenteriae cause?
inflammation oedema fibrin formation necrosis haemorrhage excessive mucus production
Which bacteria product is important for causing pathology in swine dysentery?
haemolysin
Which cells does Brachyspira usually invade?
goblet cells
What Brachyspira organism is not pathogenic?
Brachyspira innocens
What are two differences between the two species of Brachyspira which can be found in pigs?
Brachyspira innocens grows at a lower temperature (37 degrees not 42 degrees)
Brachyspira innocens causes weaker haemolysis
What three species are most susceptible to Bacillus anthracis infection?
cattle
sheep
goats
Which 2 species often die quickly and show not clinical signs when infected with Bacillus anthracis?
cattle
sheep
What are two clinical signs of anthrax in pigs?
hot painful swelling in throat area
loss of appetite
What are two clinical signs of anthrax in horses?
hot painful swelling in throat area
colic pains
What two pathologies in the throat does Bacillus anthracis cause?
necrotising tonsilits
haemorrhagic lymph nodes
What three pathologies in the intestines can Bacillus anthracis cause?
congestion
oedema
necrosis
What are the three forms of anthrax in humans?
cutaneous anthrax
pulmonary anthrax
intestinal anthrax