General anesthetics Flashcards
What effect does cardiac output have on the induction of inhalation anesthetics?
Increased cardiac output slows induction
What effect does solubility have on inhalation anesthetics?
The more soluble they are, the longer they take to equilibrate and work
What does partial pressure have to do with general anesthetics?
The partial pressures, NOT concentrations, drive movement across compartments
What is the most common general anesthetic for surgeries?
Propofol
What drug is the most cardiovascularly stable?
Etomidate
What drug is preferential for use in asthmatics?
Ketamine
Describe the differences in blood pressure changes with the three most common general anesthetics.
Propofol: drop in BP
Etomidate: little change in BP
Ketamine: increases BP
What neurotransmitter is most commonly affected by general anesthetics?
GABA
What three things influence potency of anesthetics?
Temperature, age, and other medications
What four things do NOT influence potency of anesthetics?
Sex, oxygenation, blood pH, blood pressure
What’s the formula for inhalation anesthetics?
Fa/Fi
alveolar/inspired
What is uncoupling?
Increase in blood flow, but cerebral metabolic rate of the brain goes down
What receptor does ketamine affect?
NMDA antagonist
