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Pharmacology exam 2 > Adrenergic agonists > Flashcards

Adrenergic agonists Flashcards

1
Q

Second messenger system of alpha 1

A

Coupled to PLC in vascular smooth muscle. Gaq stimulates PLC, releasing IP3 and DAG. IP3 signals for more intracellular calcium -> increased contraction and vasoconstriction

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2
Q

Second messenger system of alpha 2

A

Inhibits AC, reduces cAMP, reducing PKA activation. Less calcium influx during membrane depol and decreased release of NT.

Also causes vasoconstriction through blockade of MLCK phosphorylation, allowing for MLCK to remain active and cause vasoconstriction.

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3
Q

Second messenger system of beta 1

A

Adenylyl cyclase increases cAMP, activates PKA, phosphorylates calcium channels for increased inward calcium current and faster nodal cell depolarization. Also increases L-type calcium channels, releasing more calcium each time the heart pumps.

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4
Q

Order of affinity for A1

A

epi>NE»isoproterenol

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5
Q

Order of affinity for A2

A

epi>NE»isoproterenol

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6
Q

Order of affinity for B1

A

isoproterenol>epi=NE

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7
Q

Order of affinity for B2

A

isoproterenol>epi»NE

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8
Q

Differing affinities at different concentrations of epinephrine

A

At low doses, it has more affinity for beta receptors. Alpha effects will mask this at higher concentrations.

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9
Q

Toxicity of epinephrine

A

Arrhythmias

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10
Q

Toxicity of norepinephrine

A

Ischemia

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11
Q

Toxicity of dopamine

A

Hypotension at low rates

Ischemia at high rates

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12
Q

Toxicity of isoproterenol

A

Tachyarrhythmias

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13
Q

Toxicity of terbutaline/albuterol

A

Tremor
Tachycardia
Tolerance

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14
Q

Toxicity of phenylephrine

A

Hypertension

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15
Q

Toxicity of clonidine

A

Dry mouth

Hypertensive crisis after acute withdrawal

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16
Q

Indication of norepinephrine

A

Vasodilatory shock

17
Q

Indication of dopamine

A

Cardiogenic shock

18
Q

Indication of dobutamine

A

Short term treatment for CHF

19
Q

Indication of phenylephrine

A

SVT
Mydriatic agent
Nasal congestion

20
Q

Indirectly acting sympathomimetics

A

Meth, amphetamine, ephedrine, tyramine

21
Q

Toxic side effects of indirectly acting sympathomimetics

A

Tachycardia

22
Q

Therapeutic uses of indirectly acting sympathomimetics

A

ADD
Nasal congestion
Narcolepsy

Pharmacology exam 2 (10 decks)

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