General Adult Flashcards

1
Q

Common commorbidities with depression

A

Alcohol >40%
Anxiety >40%
PD 30%

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2
Q

How many people with depression attempt suicide?

A

9%

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3
Q

Duration of depressive episodes

A

Untreated 6-13 months

Treated 1-3 months

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4
Q

How many people have only one episode of depression?

A

50%

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5
Q

How likely are you to have another episode of depression if you have had two episodes?

A

70%

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6
Q

How likely are you to have another episode of depression if you have had three episodes?

A

80-95%

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7
Q

When is depression considered to be in remission?

A

> 3m without symptoms

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8
Q

When is someone considered to be recovered from depression?

A

> 6m without symptoms

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9
Q

Treatment for mild depression

A

Watchful waiting for 2/52

CBT

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10
Q

Treatment for moderate depression

A

SSRIs, continue for at least 6m after remission

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11
Q

How long should people continue antidepressants if they have had >2 episodes already?

A

At least 2 years

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12
Q

Treatment for severe depression

A

SSRI + CBT together

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13
Q

What to consider if someone is not responding to medication for depression

A
Adequate dosage
Lack of adherence
Axis 2 disorder (PD)
Alcoholism
Alternate diagnosis
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14
Q

Prevalence of bipolar

A

1.5%

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15
Q

Lifetime prevalence of depression

A

13%

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16
Q

1 year prevalence of depression

A

5.3%

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17
Q

Suicide rate in bipolar

A

15-18 times higher than general population

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18
Q

How many people with bipolar have another mental illness?

A

66%

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19
Q

Comorbid disorders common with bipolar

A

Anxiety - increases risk of relapse of depression
Substance misuse - increases risk of relapse of mania
Impulse disorders

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20
Q

How long does it take to recover from mania when treated?

A

4-5 weeks

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21
Q

What defines rapid cycling

A

4 or more episodes a year

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22
Q

What is ultra rapid cycling

A

4 or more episodes a month

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23
Q

Characteristics of rapid cycling bipolar

A
80% women
Early onset of illness
More severe depression and mania
Lower global functioning
Poor response to Lithium
Hypothyroid
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24
Q

DSM duration criteria for hypomania

A

4 days

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25
DSM duration criteria for mania
7 days
26
First line treatment for mania if untreated
Haloperidol Olanzapine Risperidone Quetiapine
27
Treatment for mania if known bipolar and on treatment
Increase dose of mood stabiliser Check serum Li levels Consider adding antipsychotic to lithium or valproate - especially if incongruent psychotic sx ECT
28
Treatment for Depression in bipolar
Psychological intervention Moderate to severe: fluoxetine with olanzapine Quetiapine Lamotrigine (second line)
29
When to consider long term maintenance treatment in bipolar
* after a manic episode involving significant risk and adverse consequences * bipolar I disorder with two or more acute episodes * Bipolar II disorder with significant functional impairment, or risk.
30
First line maintenance treatment for bipolar
Lithium
31
What can Lithium reduce risk of in bipolar?
Suicide Mania Depression
32
Other maintenance options in bipolar
``` Valproate Olanzapine Quetiapine Carbamazepine Lamotrigine ```
33
Management of rapid cycling
R/o hypothyroid and substance use and medication non-compliance Stop antidepressant Lithium, valproate or lamotrigine
34
How long to continue medication for maintenance after episode of bipolar?
2 years | 5 years if high risk factors for relapse
35
What can CBT offer in Bipolar
Psychoeducation Self monitoring Self regulation; action plans and modification Compliance
36
How much is increase of SCZ increased in migrants?
3-5x more
37
How much is increase of SCZ increased in urban areas?
2x more
38
M:F ratio of SCZ
1.4:1
39
Lifetime prevalence of SCZ
4 in 1000
40
M:F ratio of delusional disorders
1.18:1
41
Incidence of delusional disorders
0.7-1.3 per 100,000
42
Psychosocial treatments in SCZ
``` Psychoeducation CBT Family therapy if high EE Social skills training Vocational rehab ```
43
How many patients with FEP relapse if not treated
61%
44
How many patients with FEP relapse if treated
27%
45
Lifetime suicide prevalence in those with SCZ
5.6%
46
Good prognostic factors for SCZ
``` Late onset Obvious precipitating factors Acute onset Good premorbid adjustment Affective symptoms (esp. depression) Being married Family history of affective disorders Good social support Positive symptoms only Good initial response to treatment (best predictor) ```
47
Poor prognostic factors for SCZ
``` Early onset* (not strong) No precipitating factors** Insidious onset** Poor premorbid adjustment Social withdrawal Single, divorced, or widowed Family history of schizophrenia* (weak, controversial) Poor social network, High EE families Negative symptoms Poor compliance Neurological signs and symptoms History of perinatal trauma No remissions in 3 years Many relapses History of violence ```
48
Negative sx if SCZ
``` Anhedonia Avolition Apathy Amotivation Restricted affect. ```
49
Prevalence of negative symptoms in patients with SCZ
20-30%
50
First line treatment for SCZ
4-6 weeks of PO atypical - amisulpride, aripiprazole, olanzapine, quetiapine, risperidone
51
Risk of relapse following FEP in next 5 years
4-5x chance
52
Duration of maintenance treatment following FEP and remission
1-2 years
53
Duration of maintenance treatment following multiple episodes of SCZ and in remission
At least 5 years
54
NICE definition of treatment resistant SCZ
Lack of satisfactory clinical response to sequential use of at least two antipsychotics for a period of 6 to 8 weeks: at least one of the agents must be from atypical (non-clozapine) group.
55
Mean age of onset of GAD
30
56
Mean age of onset of panic disorder
22-25
57
Mean age of onset of OCD
20
58
Mean age of onset of social phobia
15
59
Treatment of anxiety disorders
Rule out comorbidities and previous response to treatment Psychological therapy first line SSRIs Combination in complex disorders refractory to treatment
60
Lifetime prevalence of OCD
2-3%
61
M:F ratio of OCD
1.5:1
62
Characteristics of OCD in men
Earlier onset More severe Tics Poorer outcome
63
Four categories of OCD sx
• Aggressive, sexual, and religious obsessions, and checking compulsions; • Symmetry and ordering obsessions and compulsions; (often chronic and treatment resistant) • Contamination obsessions and cleaning compulsions; • Hoarding obsessions and compulsions (may be neurobiologically distinct and often treatment resistant)
64
Treatment of mild to moderate OCD
First line: self-help Second: CBT with ERP Third: SSRIs +/- CBT
65
Treatment of severe OCD
SSRIs and CBT | If no response, switch to another SSRI or Clomipramine
66
How many patients with OCD improve on SSRIs/Clomipramine?
60-70%
67
Lifetime prevalence of PTSD
3. 6% men | 9. 7% women
68
M:F ratio PTSD
1:2
69
How many people exposed to trauma develop PTSD?
30%
70
Who is PTSD more common in?
``` Younger Higher anxiety response to initial event External locus of control Previous mental illness Female Low socioeconomic and educational status Ethnic minority Cluster B PD Perceived threat to life Peritraumatic dissociation Severity of trauma Lack of social support Subsequent life stressors Physical illness - chronic pain ```
71
Protective factors of PTSD
High IQ Higher social class Opportunity to grieve for loss
72
Initial management of PTSD if symptoms mild
Watchful waiting if <4 weeks after trauma
73
Treatment for PTSD
Psychological treatment
74
Who should be offered trauma-focused CBT in PTSD?
Severe PTSD in first month after traumatic event | PTSD within first 3 months of trauma
75
What does trauma-focused CBT involve?
Exposure therapy, cognitive therapy and stress management
76
Treatment for PTSD sx after 3 months of trauma
Trauma-focused CBT or EMDR Up to 12 sessions
77
When should medication be considered for PTSD?
If limited improvement from psychological therapy
78
Medications used in PTSD
Paroxetine Mirtazapine Amitriptyline Phenelzine
79
What is exposure therapy in in trauma focused CBT?
Repeated confrontation of traumatic memories and repeated exposure to avoided situations with relaxation and anxiety reduction
80
How long should trauma-focused treatment for PTSD continue for?
Weekly for 8-12 sessions
81
What is the cognitive component of trauma focused CBT?
Modification of misinterpretations that lead to overestimation of current threat and modification of other beliefs related to traumatic experiences and behaviour during trauma via cognitive restructuring
82
Theory of EMDR
Allows processing of traumatic memories in the form of eye movements
83
What happens in EMDR
While the patient focuses on specific images, negative sensations and associated cognitions, bilateral stimulation is applied to desensitize the individual to these memories and more positive sensations and cognitions are introduced.
84
Duration of sx in acute stress disorder
2-3 days
85
Lifetime prevalence of GAD
5%
86
Risk factors for GAD
``` Exposure to trauma Bullying Life events First degree relative of GAD Female ```
87
First line treatment of GAD
SSRI
88
Other meds for GAD
SNRI | Pregabalin
89
What does CBT involve for GAD
Education Relaxation training Exposure and cognitive restructuring
90
SSRIs for acute treatment in GAD
Escitalopram Paroxetine Sertraline
91
Non-SSRIs for acute treatment of GAD
Imipramine Venlafaxine Duloxetine Buspirone
92
Long-term meds for GAD for relapse prevention
Paroxetine Escitalopram Venlafaxine Pregabalin
93
Adjuncts with antidepressants for GAD where limited response
Olanzapine or Risperidone in low doses
94
Prognosis of GAD
42% patients recover in 12 months | Poorer outcome if another anxiety disorder
95
Types of social phobia
Generalised - fear occurs in most social situations | Situational - fear of public speaking or performance anxiety
96
Medications for social phobia
SSRI first line | Venlafaxine
97
Which SSRIs to use in social phobia
Fluoxetine Sertraline Escitalopram Fluvoxamine
98
How long to continue medication in social phobia after remission?
6-12 months
99
Second line treatment for social phobia
Phenelzine
100
Third line treatment for social phobia
SSRI and clonazepam Gabapentin Pregabalin
101
Mean age of onset of any panic attack
22 years
102
Treatment for panic disorder
CBT - 7-14 hours, weekly 1 hour sessions, complete within 4 months Self-help SSRIs
103
Medications to consider if no response to SSRIs for panic disorder
Imipramine | Clomipramine
104
Longer term treatment/prevention of panic disorder
Cognitive therapy with exposure | Continue meds for 6 months
105
Prevalence of hypochondriasis
0.8-4.5%
106
Point prevalence of panic disorder
0.9%
107
Point prevalence of social phobia
2.8%
108
Point prevalence of GAD
2-3%
109
Treatment for hypochondriasis
CBT including group CBT | SSRIs
110
Predisposing factors for BDD
Low self-esteem Critical parents and significant others Early childhood trauma Unconscious displacement of emotional conflict
111
Co-morbidities of BDD
Depression 26% Social phobia 16% OCD 6%
112
How many patients with BDD seek cosmetic surgery
7-15%
113
Treatment of BDD
High dose SSRIs for longer duration than as antidepressant - Fluoxetine CBT combination in treatment resistance case
114
Outcome of BDD
Poor - waxing and waning course | Preserved psychosocial functioning
115
Prevalence of somatisation disorder
1-2%
116
M:F ratio of somatisation disorder
1:2
117
Treatment for Somatisation disorder
CBT | Antidepressant medications
118
Aetiology of dissociative disorder
Childhood psychological abuse - 57-90%
119
Aim of treatment for dissociative disorder
Integrate feelings, perceptions, thoughts and memories
120
Treatment of dissociative disorder
Individual structured psychotherapy such as Acceptance and Commitment Therapy and DBT
121
Prevalence of anorexia
0.5-1% in teenage girls
122
Prevalence of bulimia
1-2% in 16-35 age group
123
Co-morbidities in anorexia
65% have depression 34% have social phobia 26% have OCD
124
Risk factors for ED
FHx of ED for anorexia FHx of substance misuse and obesity for bulimia Females, adolescence and early adulthood Adverse parenting - low contact and high expectations and parental discord Critical comments about eating, shape and weight from others Childhood sexual abuse Occupational and recreational pressure to be slim Low self-esteem and perfectionism History of obesity in bulimia
125
What characterises binge eating disorder?
Recurrent episodes of binge eating without extreme weight-control behaviour
126
Treatment of BED
Self help - first line Behavioural weight loss programmes CBT and IP
127
Treatment of bulimia
CBT - 20 sessions over 5 months
128
Prognosis of bulimia
33-50% make complete and lasting recovery | Antidepressants can decline frequency of binge eating and purging but effect not sustained
129
Good prognostic factors for anorexia
Illness present for <6 months No bingeing or vomiting Cooperative parents willing to participate in family therapy
130
Treatment for anorexia
CAT or CBT IPT Family interventions
131
Meds for bulimia
SSRI - fluoxetine up to 60mg OD
132
Prevalence of PD
5-13%
133
M:F ratio of dissocial PD
5:1
134
Prevalence of dissocial PD in prisons
63% male remand 49% sentenced 31% female prisoners
135
Prevalence of EUPD
2% in general population
136
M:F ratio of EUPD
1:3
137
How common is EUPD in patients with first degree relatives of EUPD?
5x more common
138
What sx of EUPD decline rapidly with time?
``` Quasi-psychotic thoughts Self-harm Help-seeking suicide efforts Treatment regressions Countertransference problems ```
139
Which sx of EUPD are more stable over time?
Depression, anger, loneliness and feelings of emptiness | General impulsivity
140
Prognosis of EUPD
40% remit after 2 years | 88% no longer meet criteria in 10 years
141
Things to cover in OCD history taking
* Obsessional thoughts-ideas, images or impulses, own thought, unpleasurable, repetitive, resistance & response * Compulsive acts/rituals-washing, cleaning, checking, counting, The anxiety symptoms associated with it. * Resistance and avoidance * Duration, effects and coping * Avoidance and anticipatory anxiety * Rule out co-morbidity-depression, anxiety
142
What to ask about obsessional thoughts
``` Own thought, Unpleasurable, Repetitive, Resistance Response ```
143
Structure of PTSD hx station
1. Details of the traumatic incident itself 2. Look for core features of post-traumatic stress disorder (PTSD) that includes hyperarousal, intrusions and avoidance 3. Assess the mode of onset, duration, progression of current symptoms and impairment in different areas of functioning (Social and occupational functioning) 4. Rule out co-morbidity.
144
PTSD sx of hyperarousal
1. Persistent anxiety and Irritability or outbursts of anger 2. Insomnia 3. Poor concentration and exaggerated startle response
145
PTSD sx of instrusions
1. Intensive intrusive imagery (flashbacks) 2. Vivid memories 3. Recurrent distressing dreams and nightmares
146
PTSD sx of avoidance
1. Actual or preferred avoidance of circumstances resembling or associated with the stressor 2. Emotional detachment and inability to feel emotions 3. Diminished interest in activities.
147
Questions to explore traumatic incident in PTSD hx
Explore the details of the accident, in particular the perceived severity and establish the level of distress and fear at the time of the event. • Could you describe the accident please? (Here approach the patient empathetically as it is difficult to talk about traumatic incidents, and acknowledge the patients distress.) • Find out about when it happened, how (terrifying) it was? • Ask about any injuries in particular head injury, loss of consciousness, whether any other person was injured etc. • Inquire about any blame, litigation, court cases and their outcome.
148
Questions about intrusions in PTSD
* How often do you think about the accident? * Do you sometimes feel as if the accident is happening again? * Do you get flashbacks? * Have you revisited the scene? * Do you get any distressing dreams/nightmares of the event? * What would happen if you hear about an accident? * Do you have any difficulties remembering parts of the accident?
149
Questions about hyperarousal in PTSD
* Have you had the feeling that you are always on the edge? * Do you tend to worry a lot about things going wrong? (Feeling anxious) * Do you startle easily? (Enhanced startle response) * Tell me about your sleep please. (Explore for sleep disturbance) * Are you sometimes afraid to go to sleep? * How has your concentration been recently? * How has your memory been lately? * Do you loose your temper more often that you used to? (Irritability)
150
Questions about avoidance in PTSD
• How hard is it for you to talk about the accident? • Do you deliberately try to avoid thinking about accidents? • Have you been to the place where the accident happened? • Do you make any effort to avoid the thoughts or conversations associated with the trauma? How would you do that? • Do you make any effort to avoid activities, places or people that arouse recollection of the trauma?
151
Construct of PTSD hx taking
Obtain details of the traumatic accident- nature and extent of the problem, severity of symptoms and impairment on current functioning Hyper arousal Symptoms (Persistent Anxiety, irritability, Poor concentration, insomnia, enhanced startled response etc) Intrusions (flashbacks, nightmares, Recurrent distressing Day dreams) Avoidance of reminders of the events (Place, person and activities), emotional detachment, numbness Rule out co-morbidity, coping strategies (Depression, anxiety, substance misuse etc)
152
Areas to cover in dementia history taking
``` • Mode of onset, duration and progression of the symptoms • Ask in detail about cognitive, behavioural, psychological, physical and - biological symptoms • Risk assessment • Past medical history • Past psychiatric history • Relevant personal history • Relevant family history. ```
153
Cognitive sx to explore in dementia history taking
Short term vs long term memory Attention and concentration Temporal and spatial - time of day, wandering, losing way home Visuospatial/agnosia - recognising places and familiar faces Nominal dysphagia - names of people Language difficulties - way they speak, word-finding difficulties, understanding others ADLs Handling money Planning and making decisions, everyday problems
154
Behavioural sx to explore in dementia history taking
• Has there been any change in his behaviour like being more irritable than usual? • Have you noticed any change in personality that seems to have occurred recently? • Ask about becoming aggressive frequently, episodes of violent and anger outbursts • Also enquire about behaving inappropriately, socially withdrawn, wandering at nighttime, disinhibited behaviour, repetitive behaviours etc.
155
Construct of dementia hx taking
Presenting problems: Onset, duration, severity and progression Impact on normal functioning Memory & confusion- Short term and long term memory impairment with examples Orientation to time & place Attention & concentration, Visuospatial dysfunction Language/communication difficulties, Recognition, naming difficulties, Reading, writing etc Functional abilities- simple ADLs (Personal ADLs ) Complex ADLs- Domestic ADLs & Community ADLs Risk assessment- self-neglect, wandering, aggression, non compliance etc
156
Risks in dementia station
``` Self-neglect Falls Wandering Self-harm Non-compliance Fires Financial abuse Aggression/others Driving Carer burnout ```
157
Exploring wandering in dementia station construct
Identify specific behavioural problems- Nature, Mode of onset, duration and progression of symptoms, Identify triggers Explore Psychiatric symptoms that could be causing these problems – Depression/psychosis, dementia. Rule out Physical problems- constipation, UTI, pain, infection Assess environmental factors and Change in social environment 1. New resident disturbing the patient 2. Lack of stimulation and Regular visitors Other factors- Loss of mobility + loss of gardening activity, Lack of routines Structured activities at home to overcome boredom (Music, art, activity nurse, pet animals, bingo, games etc) Psychosocial interventions to improve quality of life (Reminiscence therapy/reality orientation)
158
Construct for vascular dementia history taking
``` Mode of onset, duration and progression of symptoms Further exploration of presenting symptoms (H/O Major strokes and TIAs) Cognitive symptoms (Short term; long term memory, Orientation, Intermittent confusion)- Seek examples Other areas of cognitive domains- Language difficulties, Visuospatial difficulties, recognition, reading, writing etc Assess Functional abilities- ADL skills Mood and Psychological Symptoms (Depression, anxiety, paranoia, delusions, hallucinations) Physical Symptoms- (Incontinence, gait disturbance, sensory & Motor deficits, aphasia, Parkinsonian movements) Medical History (Diabetes, Hypertension, Heart disease, high cholesterol etc) & Medications Personal and family history Risk assessment (Falls, aggression, wandering, Non-compliance, carer’ stress) ```
159
Testamentary capacity criteria
It refers to the capacity to make a valid will. The will may be legally valid if the testator is of “Sound disposing mind” at the time of making it. This depends on four legal criteria. ü Whether the testator understands what a will is and what the consequences are (Is ware of what a will constitutes) ü Basic understanding of the nature and extent of the property. (Knows the general extent of their assets) ü He/she must be aware of the people who might reasonably expect to benefit from the assets (should know the name of close relatives and can assess their claims to the property) ü He/She should be free from an abnormal state of mind and must be free of delusional beliefs that might affect the distribution of assets and must not be under the influence of any drugs that tend to distort the patient’s mental capacity as far as making a will is concerned.