Gene Recombination/Mapping

Question 1

position that a gene occupies in a chromosome or within a segment of genomic DNA

Answer 1

Locus

Question 2

those gametes produced by an individual that have the same genotype at the loci of interest as those of the gametes that formed the individual

Answer 2

parental gamete

Question 3

those gametes produced by an individual that have a different genotype at the loci of interest from the gametes that formed the individual

Answer 3

recombinant gamete

Question 4

Genes on the same chromosome

Answer 4

syntenic

Question 5

nonrandom distribution into the gametes of a population of the alleles of genes that reside on the same chromosome. The greater the degree of linkage the less random the distribution of alleles is

Answer 5

Linkage disequilibrium

Question 6

the alleles of two genes that are on the same chromosome are said to be in…

Answer 6

coupling

Question 7

when the two alleles lie on the homologues, they are in…

Answer 7

repulsion

Question 8

Exocrine pancreatic insufficiency. Chronic obstructive pulmonary disease. Elevation of sodium and chloride concentration in sweat.

Answer 8

Cystic fibrosis

Question 9

Inheritance pattern of cystic fibrosis

Answer 9

autosomal recessive

Question 10

the approach of cloing a gene purely on the basis of its map position, without knowing much if anything about what the gene does or what its molecular function may be

Answer 10

positional cloning

Question 11

A large set of genetic markers spaced every 0.5 cM is now available. If there is no suspected candidate gene/locus, then the gene of interest is tested for linkage to each marker in this large set of genome-wide markers

Answer 11

Genome-scan linkage analysis

Question 12

if a gene in suspected to lie in a particular region, you can directly test for linkage to markers in this region; this information can be used to rule out or rule in a suspected disease gene that as already been mapped

Answer 12

candidate gene approach

Question 13

logartihim of the ratio of the likelihood that a given pedigree can be obtained given a recombination frequency compared to the likelihood that the pedigree arose where there was no linkage between the genes in question

Answer 13

LOD score

Question 14

If the LOD score or ratio (Z) is > or = to ____ then the genes are linked

Answer 14

3

Question 15

If Z is less than or equal to -2…

Answer 15

the genes are unlinked

Question 16

inheritance pattern of neurofibromatosis type 1

Answer 16

autosomal dominant

Question 17

Places genes into speific cytogenetic bands of the karyotype

Answer 17

Cytogenetic map

Question 18

Orders genes and genetic markers by recombination distances (cM)

Answer 18

Linkage or Genetic Map

Question 19

Orders genes and genetic markers along the DNA strand of a particular chromosome. Distances between markers are measures in kilobases

Answer 19

Physical Map

Question 20

Can be thought of as a map of sorts because it represents an array of all the genes and markers it encodes

Answer 20

DNA sequence

Question 21

A genetic locus in a population at which the most common allele has a frequency less than 0.95

Answer 21

polymorphic