Gastrointestinal - Pharmacology Flashcards
cimetidine
H2 blocker decrease H+ secretion by parietal cells inhib CYP 450 antiandrogenic effects cross b3, placenta decrease renal excretion creatinine
ranitidine
H2 blocker
decrease H+ secretion by parietal cells
decrease renal excretion creatinine
famotidine
H2 blocker
decrease H+ secretion by parietal cells
nizatidine
H2 blocker
decrease H+ secretion by parietal cells
omeprazole
PPI irreversibly inhibit H+/K+ ATPase in stomach parietal cells C. diff infxn risk pneumonia risk long term: hip fractures, low serum Mg2+
lansoprazole
PPI irreversibly inhibit H+/K+ ATPase in stomach parietal cells C. diff infxn risk pneumonia risk long term: hip fractures, low serum Mg2+
esomeprazole
PPI irreversibly inhibit H+/K+ ATPase in stomach parietal cells C. diff infxn risk pneumonia risk long term: hip fractures, low serum Mg2+
pantoprazole
PPI irreversibly inhibit H+/K+ ATPase in stomach parietal cells C. diff infxn risk pneumonia risk long term: hip fractures, low serum Mg2+
dexlansoprazole
PPI irreversibly inhibit H+/K+ ATPase in stomach parietal cells C. diff infxn risk pneumonia risk long term: hip fractures, low serum Mg2+
bismuth, sucralfate
bind to ulcer base, provide physical protection, allow HCO3- secretion to reestablish pH gradient in mucus layer
misoprostol
PGE1 analog increase production, secretion of gastric mucous barrier decrease acid production prevent NSAID ulcers maintain patent ductus arteriosus ripens cervix AE: diarrhea
octreotide
long-acting somatostatin analog
Tx: acute variceal bleeds, acromegaly, VIPoma, carcinoid tumors
AE: N, cramps, steatorrhea
antacid use
affects absorption, bioavailability, urinary excretion of other drugs (alter pH)
hypokalemia
antacid: aluminum hydroxide
AEs
constip hypophosphatemia prox mm. weakness osteodystrophy seizures
antacid: magnesium hydroxide
AEs
diarrhea
hyporeflexia
HTNo
cardiac arrest
