GASTROINTESTINAL DRUGS Flashcards
Prevent expulsion of stomach contents by decreasing stimulation of either the chemoreceptor trigger zone, near the medulla, or the vomiting center in the medulla
PREVENTS?
ANTI-EMETICS; Nausea/Vomiting
Dramamine
Phenergan
Antihistamines
Scopolamine
Anticholinergic
Thorazine
Phenothiazines
Granisetron Ondansetron
Serotonin receptor antagonist
non-pharmacologic measures for nausea/vomiting
Dry toast, Tea, Crackers
Store anti-emetics drug in____ & _____ container.
tight, light resistant
Neutralize gastric acid
ANTACIDS
Aluminum hydroxide,
Magnesium hydroxine
AlOH + MgOH (Maalox/Magaldrate)
are used for?
Peptic ulcers, reflux esophagitis, hiatal hernia
Adverse reaction of aluminum compounds
Constipation
Adverse reaction of Magnesium compounds
DIARRHEA
ANTACIDS are administered with?
8 oz of glass water
Recommended diet high in?
Calcium, Iron
Inhibit secretion of pepsin
Block release of histamines
ANTI-PEPTIC ULCER DISEASE
4 types of ANTI-PEPTIC ULCER DISEASE
- Proton-pump Inhibitor (PPI)
- H2-receptor Blockers
- Cytoprotective agent
- Anti-cholinergics
Omeprazole
Lansoprazole
Proton-pump Inhibitor (PPI)
Cimetidine
Ranitidine
Famotidine
H2-receptor Blockers
Sucralfate
Misoprostol
Cytoprotective agent
Chlordiazepoxide
Atropine sulfate
Anti-cholinergics
Anti-peptic ulcer disease is used for management of
peptic ulcer disease, GERD; protects gastric mucosa from hydrochloric acid production
Anti-peptic ulcer disease is given on
EMPTY STOMACH
Avoid____ within 30 minutes of sucralfate
Antacids
Avoid antacids within ____ hours of other anti-ulcer drugs
1-2
Administer other drugs one to two hours after ____
Sucralfate
MUST AVOID when taking ati-peptic ulcer disease
alcohol, spicy food and caffeinated beverages.
full effect takes
2 weeks
Forms the stool; Tx for diarrhea
ANTI-DIARRHEAL
Kaolin and Pectin
Fluid absorbents (Decrease fluid content)
Diphenoxylate hydrochloride
Loperamide hydrochloride
Motility Suppressants (Decrease GI motility)
Lactobacillus acidophilus
Enteric bacterium replacements
CI for anti-diarrheal
Ulcerative colitis
Motility suppressants may cause
physical dependence
Agents which facilitate defecation, and treat constipation
+ Increase bulk within the bowel
+ Lubricate the intestinal walls
+ Increase peristalsis
LAXATIVES
Mineral oil
Colace
Metamucil
Dulcolax
Milk of magnesia
TREATS?
Constipation
Intestinal lubricants inhibit absorption of
fat soluble vitamins
fat soluble vitamins like ____ (excrete excessive loss of water) which may cause
Saline cathartics; dehydration, hypernatremia
To treat constipation, diet must include
High fiber, fluid intake