Gastroenterology Flashcards
DDx hepatomegaly
SHIRT
Structural = EHBA, choledochal cyst
Storage/Metabolic: storage disorders (GSD), MPS, alpha1AT, Wilsons, CF
Heart = RHF
Haematological = thalassaemia, sickle cell, leukaemia/ lymphoma
Infective = EBV, CMV, hep A, B, C
Rheumatological = autoimmune, SLE, sJIA
Tumour = primary or secondary, hepatoblastoma, neuroblastoma
DDx Hepatosplenomegaly
PHIIMMC
Portal hypertension
Haematological = thalassaemia
Infective = EBV, CMV, acute viral hepatitis
Inflammatory = SLE, sJIA
Malignancy = haematological
Metabolic = lysosomal storage disorder (Gaucher, MPS, Niemann Pick)
Congenital hepatic fibrosis
DDx Splenomegaly
PHIIMM
Portal hypertension
Haematological = any chronic haemolytic disorder, hereditary spherocytosis, G6PD
Infective = EBV, SBE
Inflammatory = sJIA, SLE
Malignant = haematological malignany
Metabolic = lysosomal storage disorer (Gaucher, Nieman Pick, MPS)
DDx Jaundice + Splenomegaly
Hepatocellular - mixed or conjugated
- CLD + PHT
Haematological - unconjugated
- Haemolytic disorder
-> Enzyme - G6PD
-> Membrane -> HS
-> Haemaglobinopathies -> sickle cell
Short Gut Causes
Congenital
- Congenital short bowel
- Atresia
- Gastroschisis
Acquired
- NEC
- Volvulus +- malrotation
- Hirshprung
- Crohns
- Trauma