Gastroenterology Flashcards

1
Q

DDx hepatomegaly

A

SHIRT

Structural = EHBA, choledochal cyst
Storage/Metabolic: storage disorders (GSD), MPS, alpha1AT, Wilsons, CF
Heart = RHF
Haematological = thalassaemia, sickle cell, leukaemia/ lymphoma
Infective = EBV, CMV, hep A, B, C
Rheumatological = autoimmune, SLE, sJIA
Tumour = primary or secondary, hepatoblastoma, neuroblastoma

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2
Q

DDx Hepatosplenomegaly

A

PHIIMMC

Portal hypertension
Haematological = thalassaemia
Infective = EBV, CMV, acute viral hepatitis
Inflammatory = SLE, sJIA
Malignancy = haematological
Metabolic = lysosomal storage disorder (Gaucher, MPS, Niemann Pick)
Congenital hepatic fibrosis

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3
Q

DDx Splenomegaly

A

PHIIMM

Portal hypertension
Haematological = any chronic haemolytic disorder, hereditary spherocytosis, G6PD
Infective = EBV, SBE
Inflammatory = sJIA, SLE
Malignant = haematological malignany
Metabolic = lysosomal storage disorer (Gaucher, Nieman Pick, MPS)

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4
Q

DDx Jaundice + Splenomegaly

A

Hepatocellular - mixed or conjugated
- CLD + PHT

Haematological - unconjugated
- Haemolytic disorder
-> Enzyme - G6PD
-> Membrane -> HS
-> Haemaglobinopathies -> sickle cell

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5
Q

Short Gut Causes

A

Congenital
- Congenital short bowel
- Atresia
- Gastroschisis

Acquired
- NEC
- Volvulus +- malrotation
- Hirshprung
- Crohns
- Trauma

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