Gastro

Question 1

Primary biliary cirrhosis associations

Answer 1

Thyroid disease 
Rheumatoid arthritis 
Sjögren's syndrome 
Keratoconjunctivical sicca
Systemic sclerosis 
Renal tubular acidosis

Question 2

PBC antibodies

Answer 2

AMA

Question 3

Gilbert’s syndrome

Answer 3

Thought to be AD

Question 4

Zollinger ellison syndrome

Answer 4

Gastrin secreting adenoma, most often in pancreas 
Leads to hyper secretion of acid 
Get peptic ulcers
60% malignant 
20% associated with MEN1
20% sporadic

Question 5

Tests for Zollinger Ellison syndrome

Answer 5

Increased fasting levels of gastrin

Secretin stimulation test

Question 6

Curling ulcer

Answer 6

Gastrin ulcer after burns or trauma

Question 7

Budd chiari syndrome

Answer 7

Hepatic vein obstruction by thrombosis or tumour

Causes: hyper coagulate states or liver/renal/adrenal tumours

Treatment - TIPS

Question 8

Pharyngeal pouch pathophysiology

Answer 8

posteromedial diverticulum through Kilians dehiscence

Question 9

globus hystericus

Answer 9

history of anxiety, relieved by swallowing, usually painless

Question 10

Histology of crohns

Answer 10

transmural inflammation, non-caseating epithelial granulomas, goblet cells

Question 11

Histology of C-Diff

Answer 11

pseudomembranous, superficial ulceration of the colonic mucosa

Question 12

H.Pylori histology

Answer 12

spiral organisms in mucus in crypts

Question 13

Chemical gastritis (reflux)

Answer 13

oedematous and congested fovoelar hyperplasia, lack of inflammatory cells

Question 14

UC histology

Answer 14

no inflammation beyond submucosa, crypt abscesses

Question 15

FAP

Answer 15

AD
Chromosome 5
Loss of APC

> 100 polyps

Question 16

Coffee bean sign

Answer 16

Volvulus