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GI System > Gastritis > Flashcards

Gastritis Flashcards

1
Q

What is gastritis?

A

Inflammation of the stomach

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2
Q

Pathology can be

A

Autoimmune
Bacterial
Chemical injury
(ABC)

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3
Q

Autoimmune pathology

A

Autoanitbodies target parietal cells - atrophy and loss of specialised gastric epithelial cells - decreased acid secretion and loss intrinsic factor

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4
Q

Loss of intrinsic factor results in

A

Vitamin B12 deficiency - pernicious anaemia

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5
Q

Bacterial pathology

A

Helicobacter Pylori - acute and chronic inflammation - urease produces ammonia (alkali) - increased pH causes increase in acid secretion

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6
Q

Helicobacter Pylori

A

Gram negative bacteria found in mucus on surface of gastric epithelium
Initiates acute or chronic inflammation
Secretes urease

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7
Q

Urease

A

Enzyme secreted by H. Pylori, hydrolyses urea into ammonia and carbon dioxide

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8
Q

Causes of chemical injury

A

Drugs (NSAID’s)
Alcohol
Bile reflux

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GI System (10 decks)

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