Gastric Pharmacology

Question 1

Esomeprazole /omeprazole

Answer 1

Proton pump inhibitor: irreversibly inhibits H+/K+ ATPase

Question 2

Lansoprazole

Answer 2

Proton pump inhibitor: irreversibly inhibits H+/K+ ATPase

Question 3

Pantoprazole

Answer 3

Proton pump inhibitor: irreversibly inhibits H+/K+ ATPase

Question 4

Rabeprazole

Answer 4

Proton pump inhibitor: irreversibly inhibits H+/K+ ATPase

Question 5

Aluminum Hydroxide

Answer 5

Antacids: weak base, not systemically absorbed
AE: Constipation

Question 6

Calcium Carbonate

Answer 6

Antacids: weak base, systemically absorbed
AE: Metabolic alkalosis, Hypercalcemia

Question 7

Magnesium Hydroxide

Answer 7

Antacids: weak base, not systemically absorbed
AE: Osmotic diarrhea

Question 8

Sodium Bicarbonate

Answer 8

Antacids: weak base, systemically absorbed
AE: Alkanizes urine, fluid retention

Question 9

Cimetidine

Answer 9

Highly selective, competitive H2 antagonists - decrease all forms of gastric acid secretion
AE: Classic inhibitor of CYP450

Question 10

Famotidine

Answer 10

Highly selective, competitive H2 antagonists - decrease all forms of gastric acid secretion

Question 11

Nizatine

Answer 11

Highly selective, competitive H2 antagonists - decrease all forms of gastric acid secretion

Question 12

Ranitidine

Answer 12

Highly selective, competitive H2 antagonists - decrease all forms of gastric acid secretion

Question 13

Misoprostol

Answer 13

BASED ON MECHANISM OF ACTION: treatment of ulcers induced by nonsteroidal anti-inflammatory agents - locally reverses the action of NSAIDs in the stomach.

Question 14

Sucralfate

Answer 14

sucrose sulfate-aluminum hydroxide complex that attaches to the basement membrane of the ulcer. Requires acid environment. SE: constipation

Question 15

Bismuth subsalicylate

Answer 15

bismuth = active ingredient in the stomach, salicylic acid = responsible for most of the side effects