Gastric Motility and Pancreatic Function Flashcards
What part of the stomach has the thickest muscle layer and why?
Antrum because this is where the majority of motility occurs
What kind of muscle layer does the body have?
Thin muscle layer for weaker contractions
Does the fundus contain muscle?
Yes, but it is relatively little
How much gastric content (Chyme) enters the duodenum at a time?
Small amounts and as the sphincter contracts the antral contents are pushed back into the body for more mixing
What generates the peristaltic rhythm?
Pacemaker cells found in the longitudinal muscle layer
What does the slow wave rhythm create?
The Basic Electrical Rhythm (BER)
Slow waves due to slow de/repolarisation
How are the fibres connected?
By gap junctions so electrical activity spreads
What does gastrin lead to?
Increased contraction
What does stomach distension lead to?
Long/Short reflexes
Increased contraction
What inhibits motility?
Fat/Acid/Amino Acid/Hypertonicity in the duodenum
What is the other name for submucosal glands that secrete bicarbonate?
Brunner’s Gland duct cells
Why is bicarbonate needed to neutralise stomach pH?
Pancreatic enzymes are denatured at stomach pH so this must be resolved
What does acid in the duodenum trigger?
Bicarbonate secretion via Long (Vagal) & Short (ENS) reflexes and release of secretin from S cells
What does secretin stimulate?
Brunner’s Gland
Where does the acid and bicarbonate come from?
Acid comes down into the duodenum from the stomach
Bicarbonate comes up from the submucosa of the duodenum