Gastric Diseases Flashcards
Which parts of the stomach expand to accomodate food?
Fundus and Body
Which part of the stomach acts as the grinder?
Antrum
The outermost layer of the stomach is the
serosa
What 3 types of cells comprise the Gastric Glands
in the mucosa of the stomach?
Mucous neck cells
Parietal cells
Chief cells
What 3 cell types are considered neuroendocrine cells and
are found in the mucosa of the stomach?
ECL cells
D cells
G cells
This cells is responsible for secreting HCl and intrinsic factor
Parietal cells
What is the function of parietal cells?
Kill microbes, activate pepsinogen, and bind Vit B12
What do Chief Cells secrete?
Pepsinogen and Gastric Lipase
What is the function of Chief Cells?
Protein and fat digestion
What do Mucus-Neck Cells secrete?
Mucus and Bicarbonate
What is the function of mucus-neck cells?
To protect the stomach epithelium from acid
What do ECL Cells (Enterochromaffin Cells) secrete?
Histamine and Serotonin
What is the function of ECL Cells (Enterochromaffin Cells)?
to stimulate gastric acid secretion
What do D-cells secrete?
Somatostatin
What is the function of D-cells?
To inhibit gastric acid secretion
What do G-cells secrete?
Gastrin
What is the function of G-cell secretion?
Stimulates gastric acid secretion
Which substances are responsible for stimulating gastric acid secretion?
Gastrin and Histamine
What substance is responsible for protein digestion?
Pepsinogen (secreted by chief cells)
What substance is responsible for fat digestion?
Gastric lipase (secreted by chief cells)
Which substance inhibits gastric acid secretion?
Somatostatin (secreted by D-cells)
What substance is responsible for binding Vit. B12
allowing for its absorption?
Intrinsic factor (secreted by parietal cells)
What substance is responsible for activating pepsinogen?
HCl (secreted by Parietal Cells)
Meissner’s Plexus (nervous system component) is found
in which layer of the stomach?
Submucosa
Auerbach’s (Myenteric) Plexus is
found in this layer of the stomach
Muscularis
The H/K ATPase Pump is found in parietal cells,
which are part of this layer of the stomach
Mucosa
On a CHEM panel the following changes are noted:
BUN elevated and disproportionally higher than Creatinine
What does this finding suggest?
Bleeding in upper GI tract
On a CHEM panel the following changes are noted:
Metabolic alkalosis with increased bicarb, but decreased chloride
What does this finding suggest?
Gastric outflow obstruction
Endoscopy is unhelpful for any disease
deeper than the _________ (layer of the stomach)
mucosa
_______ is the best way to evaluate for
inflammation, ulcers, FB, and mucosal neoplasia
Endoscopy
_________ are contraindicated in treatment of gastric foreign bodies
Antiemetics
Inflammation of the mucosa is known as
Gastritis
Dramatic gastric distension of the stomach is known as
Dilatation
When the stomach twists and moves on its axis
usually to the left of the fundus, it is known as
Volvulus