Gastric Disease Flashcards
0
Q
Describe the pathophysiological features of Helicobacter pylori and how this affects gastric physiology
A
H. Pylori - motile, urease producing, adheres to gastric mucosa, cytotoxins
Increased gastrin, increased parietal cell acid production, duodenal cal damage, metaplasia
1
Q
Describe the clinical fearless and natural history of ulcer disease
A
Pain
Complications - bleeding, perforation, gastric outlet obstruction
2
Q
Describe the principles of modern ulcer treatment
A
Acid suppression medication (PPI, H2 receptor antagonist)
Antibiotics
3
Q
Describe the pathogenesis of ulcer disease
A
Acid Smoking Alcohol Stress H. Pylori NSAIDs
4
Q
Outline the wars in which gastric acid secretion may be reduced by drugs
A
Proton pump inhibitor e.g. omeprazole
H2 receptor antagonist
