Gas Transpot - Karius Flashcards
at any PO2 > 60 mmHg, how much is Hb oxygen saturated?
85%
what does a left shift in the Hb-O2 curve represent?
right shift?
INC in affinity of Hb for O2
DEC in affinity
what factors produce left shifts?
low CO2
high pH
what factors produce right shifts?
high CO2
low pH
INC temperature
INC 2,3 DPG
what does a right shift of the curve mean in the body?
inc demand for O2 in the Tissue
what is the a-v O2 difference?
what does this represent?
difference bw arterial O2 and venous O2
how much O2 used by tissue being perfused
what removes very little O2 from blood?
very high?
adipose
skeletal m.
RQ equation
what is normal?
RQ = V(dot) CO2 / V(dot) O2
0.8
what can CO2 combine with?
what does it form?
where does it bind?
plasma proteins or Hb
carbamino compounds
amine groups
what is the Haldane shift?
presence of O2 on heme DEC affinity of Hb chain for CO2
what is most of the CO2 carried in the body?
HCO3 (bicarbonate)
what is the chloride shift?
where is it occurring?
1 HCO3- out in the PLASMA and 1 Cl- in
venous blood (therefore it has lower plasma Cl- level)
what enzyme catalyzes the Cl- shift reaction?
carbonic anhydrase
what is the major transporter of O2?
CO2?
Heme in Hb
HCO3-
what is the alveolar gas equation?
PA O2 = PI O2 - (Pa CO2 / R)
