Gas Exchange Flashcards
What does Fick’s Law Describe?
What do the Variables represent?
Fick’s Law measures the Rate of Diffusion
k = the diffusion constant
A = Area for gas exchange
(P2 - P1) = Difference is Partial Pressure
D = Distance (Thickness)
What percent of oxygen is in the air?
Approx 21%
What are the Air Pressure and Partial Pressure at Sea Level?
Air Pressure is 760 mm Hg
21% of that is 760 x 0.21 = 159.6
Therefore the Partial Pressure of Oxygen is approximately 160 mm Hg
mm Hg = millimetres of Mercury
What is the Partial Pressure of Oxygen at the peak of Mt. Everest?
Approximately - 53 mm Hg
because total air pressure is much lower as elevation increases
What % of oxygen dissolves in the Blood Plasma?
What happens to the rest of it?
1.5% of the oxygen dissolves in the Blood Plasma
The remaining 98.5% binds to hemoglobin
What is Hemoglobin?
Hemoglobin is an Oxygen-transporting Protein found in our RBCs and erythrocytes. (Quaternary Structure)
It has 4 subunits.
Each subunit has a binding site where it can bind with 1 Oxygen
What happens when 1 Oxygen binds to Hemoglobin?
The binding of O2 to one subunit changes the affinity of the other subunits:
This is referred to as Cooperative Binding
Draw an Oxygen-Saturation Curve.
What does it show?
100% on the y-axis means all 4 O2 have bonded with the Hemoglobin
% of O2 changes slowly near the top and the bottom
There is a rapid increase in the middle
(Sigmoid Curve)
Graph the change in pressure of an animal at rest vs on the move (exercising).
What do you notice?
y-axis decreases at a faster rate than the x-axis
What happens to our blood as we exercise? What causes this?
(4)
-During exercise, CO2 is produced
-The CO2 dissolves in water and forms Carbonic Acid
-Blood in exercising muscles becomes more acidic
-Change in pH affects the affinity of hemoglobin to O2
-Less O2 available, more likely to release O2 into tissue
What is Carbonic Acid? How is it made?
When we exercise, we produce CO2.
That CO2 mixes with H2O to form Carbonic Acid and an extra proton.
Chemical Reaction:
What happens to oxygen levels as pH decreases?
As the pH drops, oxygen becomes less likely to stay bound to hemoglobin
We call this the Bohr Shift.
The Bohr shift makes hemoglobin more likely to release oxygen to tissues at low pH.
What happens to the Carbonic Acid in the RBC?
The carbonate is removed from the erythrocyte (RBC) by a protein (antiporter) in the membrane and is replaced with a chloride
Describe what happens to Oxygen as Maternal Blood is shared with the Fetus’s Blood.
oxygen needs to diffuse from maternal blood to fetal blood.
The fetus has different hemoglobin with higher oxygen affinity
So the graph shift would look something like this.
True or False
Animals have to take in CO2 and expel O2 to sustain cellular respiration and stay alive
FALSE
Animals have to take in O2 and expel CO2