Gametogenesis Flashcards
What is the main goal of meiosis?
-reduce chromosome #s (diploid -> haploid in gametes)
-crossing over & exchange of genetic material between male-female chromatids
-produce 4 daughter cells (genetically distinct)
Describe gametogenesis.
-formation of male & female gametes
-sperm & ova from spermatogonia & oogonia
Describe mitosis.
-spermatogonia & oogonia (gonadal stem cells) multiply within gonad with a full set or diploid # of chromosomes (2N) specific to the species
Describe meiosis I & II.
-Spermatocytes & oocytes are produced & exchange genetic material between male & female chromatids
-divide to ensure haploid # of chromosomes (1N) in sperm & ova
Describe fertilization.
-sperm penetrates ovum to restore diploid # of chromosomes (2N) to make zygote
Describe the hypothalamic-pituitary-gonadal axis.
negative feedback
Gonads = endocrine & gametogenic functions
Describe primordial germ cells.
-primary undifferentiated stem cells that will differentiate into female & male germ cells = spermatogonia or oogonia = develop into mature male & female gametes = spermatozoa or ova through spermatogenesis or oogenesis
-PGCs appear during early embryo development
-PGCs proliferate & migrate toward genital ridge of developing gonad
Describe the male gonad (testis).
Key hormones:
-GnRH
-FSH
-LH
-testosterone
-inhibin
Key mechanism:
-LH -> leydig cells -> testosterone
-FSH -> Sertoli cells -> inhibin, ABP
Describe leydig cells.
-respond to LH to make testosterone or other androgens that help w sexual development & support to Sertoli cells
Describe Sertoli cells.
-respond to FSH to make inhibin & androgen binding proteins & nourish developing sperm cells
Picture of Sertoli & cells of leydig.
Describe spermatogenesis steps.
- spermatogenesis: begins at puberty when HPG axis matures & testosterone rises (continuous after puberty)
- mitosis: spermatogonia divide to make diploid primary spermatocytes
- Meiosis I: primary spermatocytes duplicate paternal & maternal chromosomes, homologous chromosomes crossover, exchange DNA, & divide to make haploid secondary spermatocytes
- Meiosis II: divide to make spermatids
- Maturation: transform spermatids to spermatozoa or sperm
Describe sperm characteristics.
-each sperm is genetically distinct
-X or Y chromosome
-acrosome of head = enzymes to penetrate ovum
-midpiece = mitochondria to make ATP (energy to propel sperm to site of fertilization)
Describe sperm morphology in species.
shape & size of sperm head + length is species specific
-disc = ruminants
-pear = man, stallion
-hook = rodents
-spoon = guinea pig
-filiform = bird
Describe the spermatogenic cycle & wave.
12 stages
-spermatogenic cycle = time of one cycle
-spermatic wave = distance between stages