G-protein linked 2nd messangers

Question 1

Gq 2nd receptor

• inc Phospholipase C
  
  • PIP₂
    
    • DAG–> PKC
    • IP₃–>Inc Ca²⁺

Answer 1

H alpha V 1

M1 and M3

Question 2

Gs

• Adenylate cyclase
  
  • ATP–>cAMP
    
    • PKA
      
      • increase Ca (heart)
      • Myosin light chain kinase (sm muscle)

Answer 2

B1, D1,

B2, H2, V2

Question 3

Gi

• Adenylate cyclase
  
  • ATP–>cAMP
    
    • PKA
      
      • increase Ca (heart)
      • Myosin light chain kinase (sm muscle)

Answer 3

M2, A2, D2

Question 4

Define function of (cholinergic)

Hemicholinium

Answer 4

blocks up take of choline

Question 5

Define function of (cholinergic)

Vesamicol

Answer 5

blocks ACh going into vesicles

Question 6

Define function of (cholinergic)

Botulinum

Answer 6

blocks release of ACh

Question 7

Define function of (noradrenergic)

Metryosine

Answer 7

blocks conversione of Tyrosine to DOPA

Question 8

Define function of (noradrenergic)

Reserpine

Answer 8

Blocks Dopamine going into vesicles

Question 9

Define function of (noradrenergic)

Bretylium

Guanethidine (not used clincially)

Answer 9

Blocks release of dopamine

Question 10

Define function of (noradrenergic)

Amphetamine

Answer 10

increases release of Dopamine from noradrenergic neuron.

Question 11

Define function of (noradrenergic)

Cocain, TCAs, amphetamine

Answer 11

Blocks reuptake of dopamine in neuron terminal.

Question 12

Define function of (noradrenergic)

• alpha 2
• ATII

Answer 12

• Alpha 2: blocks release of dopamine
• ATII: stimulates the release of dopamine