Cytochrome P-450 interactions Flashcards
1
Q
Inducers of P-450
Chronic alcholic mona steals phen-phen never refuses greasy carbs
A
- chronic alcohol
- Modanfil (narcolopsy)
- St. Johns work (hypericum perforatum)
- Phenytoin (seizures)
- Phenobarbital (long active seizure control)
- Nevirapine (NNRT)
- Rifampin (- DNA dependent RNA polymerase)
- Griseofulvin (oral anti-fungal: ring worm)
- Carbamazepine (seizure, nerve damage or bipolar)
2
Q
Inhibitors of P-450
Acute Gentaleman Gipped Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon Rolls
A
- Acute alchol abuse
- Gemfibrozil (high cholesterol, TTG)
- Ciprofloxanin (quinolone)
- Isoniazid (TB)
- Grapefruit juice
- Quinidine (irregular HB, Class I)
- Amiodarone (life threatening arrhythmias)
- Ketoconazole (seborrheic dermitits: tinea corpis)
- Macrolides (- 50S)
- Sulfonamides (- folate synthesis)
- Ritonavir ( protease -)
3
Q
Define the substrates in P-450
Always, Always, Always, Always, think when starting others
4-A’s and TWOS
A
- Anti-epileptics
- Anti-depressents
- Anti-psychotics
- Anesthetics
- Theophylline
- Warfarin
- Statins
- OCPs
4
Q
Inducer/inhibitors
chronic alcohol use
A
Inducer
5
Q
Inducer/inhibitor
Modafinil
A
Inducer
6
Q
Inducer/inhibitor
St. John wort
A
Inducer
7
Q
Inducer/inhibitor
Phenytoin
A
inducer
8
Q
Inducer/inhibitor
Phenobarbital
A
inducer
9
Q
Inducer/inhibitor
Nevirapine
A
inducer
10
Q
Inducer/inhibitor
Rifampin
A
Inducer
11
Q
Inducer/inhibitor
Griseofulvin
A
Inducer
12
Q
Inducer/inhibitor
Carbamazepine
A
Inducer
13
Q
Inducer/inhibitor
Acute alcohol abuse
A
inhibitor
14
Q
Inducer/inhibitor
Gemfibrozil
A
inhibitor
15
Q
Inducer/inhibitor
Ciprofloxacin
A
inhibitor
