Fungal Disease - Importance and Examples Flashcards

1
Q

What is fungi?

A

Eukaryotic organism
Yeast, mould or both

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Yeast

A

Unicellular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Mould

A

Multicellular-filamentous hyphae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How do fungi digest food?

A

Externally
Absorb nutrients through cell wall

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is fungi cell wall made of?

A

Chitin and other polysaccharides
Complex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How do fungi reproduce?

A

Spore formation
* Asexual +/- sexual

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Saprophytic meaning

A

Obtain food by absorbing dissolved organic material

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which fungi are pathogenic?

A

Dermatophytes (Cause ringworm)
NEVER a commensal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How are fungi classified?

A

Based on normal habitat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Geophilic

A

Found in soil/environment
Only occasionally infect animals/man

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Zoophilic

A

Found on animals
Occasionally transmitted to man

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Anthropophilic

A

Found on man
Occasionally transmitted to animals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How do fungi cause disease?

A

Mycosis - Tissue invasion
Mycotoxicosis - Toxin production
Induction of hypersensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Types of Mycosis

A

Superficial mycoses
Subcutaneous (deep) mycoses
Systemic Mycoses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Site of superficial mycoses

A

Epidermis
Keratinised structures
Mucous membranes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Site of subcutaneous mycoses

A

Subcutaneous tissue

17
Q

Site of systemic mycoses

A

Respiratory system
Digestive system
Other organ systems

18
Q

What is mycosis predisposed by?

A
  • Immunological deficits
  • Immunosuppression
    ○ Including corticosteroid treatment
  • Immaturity
  • Ageing
  • Malnutrition
  • Prolonged antibiotic therapy
  • Exposure to heavy challenge of fungal spores
  • Traumatised tissues
  • Persistent moisture on skin surface
19
Q

Types of superficial mycoses

A

Dermatophytosis - caused by dermatophytes
Dermatomycosis - caused by non-dermatophytes

20
Q

Dermatophytosis

A

Causes ringworm
* Microsporum spp.
* Trichophyton spp.

Pathogenic fungi
Highly contagious

Mainly infect cat, cattle and horses
Can also infect dogs, goats, pigs, sheep

21
Q

Dermatomycosis

A

Non-dermatophytic fungi
* Malassezia
* Candida

Normal skin commensals that cause opportunistic infections
Not contagious

22
Q

Malassezia dermatitis

A

Type of dermatomycosis
Common dysbiosis of dogs (sometimes cats)
Often occurring secondary to other skin disease

23
Q

Candidiasis

A

Type of dermatomycosis
Candida albicans

Opportunistic infection related to immunosuppression

E.g. Mycotic stomatitis - puppies, kittens, foals
E.g. Thrush of oesophagus/crop - young chickens

24
Q

Subcutaneous (deep) Mycosis

A

Localised invasion of dermis/subcutis
Often follows foreign body penetration
Chronic localised lesions

25
Q

Chronomycosis

A

Caused by pigmented fungus

26
Q

Hyalohyphomycosis

A

Caused by non-pigmented fungus

27
Q

Mycetoma

A

○ Organism in granules/grains within lesion
○ Associated with swelling and draining sinus

28
Q

Types of mycetoma

A

Eumycotic mycetoma
Actinomycotic mycetoma

29
Q

Eumycotic mycetoma

A

Organism is fungal

30
Q

Actinomycotic mycetoma

A

Organism is bacterial

31
Q

Pseudomycetomas

A

Different granule formation to mycetoma
Can be dermatophytic or bacterial

32
Q

Systemic Mycosis

A

Organism initially inhaled then spreads to internal organs
E.g Cryptococcosis

33
Q

Cryptococcosis Issues

A

Cats :
Respiratory, cutaneous, neural/ocular infections
Dogs:
Disseminated disease with neural/ocular signs
Cattle (rare):
Mastitis, nasal granulomas
Horses (rare):
Nasal granulomas/sinusitis, cutaneous lesions, pneumonia, meningo-encephalomyelitis, abortion
Can affect man
But not usually contracted from an animal

34
Q

Cryptococcosis Examples

A

C. neoformans
C. gait
Associated with pigeon droppings which contaminate soil
Associated with decaying vegetation

35
Q

Mycotoxicosis

A

Toxin production by fungi
Mostly from fungi on crops, pasture or stored feed
Example species:
○ Penicillium
○ Aspergillus (-> aflatoxicosis)
○ Fusarium
○ Claviceps (-> ergotism)

wide range of clinical signs dependent on toxin

36
Q

Mycotoxicosis effects

A