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Pharm II > Fungal > Flashcards

Fungal Flashcards

1
Q

inhibit lanosterol 14 - alpha demethylase

A

azoles

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2
Q

reduces ergosterol content in the cell membrane and reduces membrane integrity

A

azoles

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3
Q

which drug doesnt treat aspergillus

A

flucytosine

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4
Q

which drug treats all the candida species

A

flucytosine

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5
Q

excellent CNS penetration

A

fluconazole

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6
Q

what type of toxicity was in all the azoles

A

liver toxicity

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7
Q

which azoles had ocular toxicity assocaited with it

A

voriconazole

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8
Q

which azoles has cardiac toxicity associated with it

A

itraconazole

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9
Q

which azoles has QT prolongation

A

fluconazole and posaconazole

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10
Q

first line of defense for c. albicans

A

fluconazole

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11
Q

doc for aspergillus

A

voriconazole

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12
Q

treats histoplasmosis and bastomycosis

A

itraconazole

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13
Q

treats mucorales infections and used prophylaxis in BMT patients

A

posaconazole

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14
Q

inhibit 1,3 Beta D-glucan synthase

A

echinocandins

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15
Q

blocks cell wall formation

A

echinocandins

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16
Q

fungicial against most candida species

A

echinocandins

17
Q

fungistatis against aspergillus species

A

echinocandins

18
Q

generally reserved for critically ill or those with prior azole exposure

A

echinocandins

19
Q

which of the echinocandins needs a loading dose

A

caspofungin and anidulafungin

20
Q

how are echinocardins administered?

A

iv

21
Q

pokes holes in the membrane and depolarizes the cell

A

amphotericin

22
Q

cheapest amphotercicin and the one UMC uses

A

abelcet

23
Q

nephtrotoxicity and electrolyte abnormalities, infusion-related rigors and thrombophlebitis

A

amphotericin

24
Q

pyrimidine analog, related to 5-fluorouracil, available only orally

A

flucytosine

25
Q

excellent CNS penetration

A

flucytosine (and fluconAZOLE)

26
Q

superifical infections, used for onochomycosis, high fat meal, contraindicated with PCN allergy

A

grisefulvin

27
Q

inhibits squalene epoxidase, mucocutaneous infections, ADRS (weight gain and N/V)

A

terbinafine

Pharm II (13 decks)

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