Fungal Flashcards
inhibit lanosterol 14 - alpha demethylase
azoles
reduces ergosterol content in the cell membrane and reduces membrane integrity
azoles
which drug doesnt treat aspergillus
flucytosine
which drug treats all the candida species
flucytosine
excellent CNS penetration
fluconazole
what type of toxicity was in all the azoles
liver toxicity
which azoles had ocular toxicity assocaited with it
voriconazole
which azoles has cardiac toxicity associated with it
itraconazole
which azoles has QT prolongation
fluconazole and posaconazole
first line of defense for c. albicans
fluconazole
doc for aspergillus
voriconazole
treats histoplasmosis and bastomycosis
itraconazole
treats mucorales infections and used prophylaxis in BMT patients
posaconazole
inhibit 1,3 Beta D-glucan synthase
echinocandins
blocks cell wall formation
echinocandins
fungicial against most candida species
echinocandins
fungistatis against aspergillus species
echinocandins
generally reserved for critically ill or those with prior azole exposure
echinocandins
which of the echinocandins needs a loading dose
caspofungin and anidulafungin
how are echinocardins administered?
iv
pokes holes in the membrane and depolarizes the cell
amphotericin
cheapest amphotercicin and the one UMC uses
abelcet
nephtrotoxicity and electrolyte abnormalities, infusion-related rigors and thrombophlebitis
amphotericin
pyrimidine analog, related to 5-fluorouracil, available only orally
flucytosine
excellent CNS penetration
flucytosine (and fluconAZOLE)
superifical infections, used for onochomycosis, high fat meal, contraindicated with PCN allergy
grisefulvin
inhibits squalene epoxidase, mucocutaneous infections, ADRS (weight gain and N/V)
terbinafine
