Chapter 61 - Derm Drugs

Question 1

___ may be long enough to permit once-daily application of drugs with short systemic half lives

Answer 1

local half life

Question 2

application of a plastic wrap to hold the drug and its vehicle in close contact with the skin

Answer 2

occlusion

Question 3

__ is extremely effective in maximizing efficacy

Answer 3

occlusion

Question 4

what are convenient for application to the scalp and hairy areas

Answer 4

tinctures, lotions, fels, foams, and aerosols

Question 5

emulsified vanishing type creams may be used in ___ without causing maceration

Answer 5

intertriginous areas

Question 6

__ provides homogeneous, stable preparations when mixtures of immiscible liquids such as oil-in-water creams are compounded

Answer 6

emulsifying agents

Question 7

topical ___ agents may be useful in preventing infections in clean wounds, in the early treatment of infected dermatoses and wounds, in reducing colonization of the nares by staph, in axially deodorization and the management of acne vulgaris

Answer 7

antibacterials

Question 8

in treatment of secondarily infected ___, which are usually colonized with strep, staph or both, combination therapy may prove superior to corticosteroid therapy

Answer 8

dermatitis

Question 9

antibiotic-corticosteroid combinations may be useful in treating __, __ and __

Answer 9

diaper dermatitis, otitis externa, and impetiginized eczema

Question 10

___ and ___ are peptide antibiotics, active against gram +, strep, pneumococci and staph

Answer 10

bacitracin and gramicidin

Question 11

__ is poorly absorbed through the skin, so systemic toxicity is rare

Answer 11

bacitracin

Question 12

topical use only, can be in combination with neomycin, polymyxin, bacitracin and nystatin

Answer 12

gramicidin

Question 13

most gram + aerobic bacteria and MRSA are sensitive to __

Answer 13

mupirocin

Question 14

effective treatment of impetigo caused by s. aureus and group A,b strep

Answer 14

mupirocin

Question 15

peptide antibiotic that is effective against gram - , pseudomonas aeroginosa, e.coli, enterobacter and klebsiella

Answer 15

polymyxin B sulfate

Question 16

hydroalcoholic vehicle and foam formulation may cause drying and irritation of the skin which complaints of burning and stinging in this antibiotc for acne

Answer 16

clindamycin

Question 17

topical __ is effective in the treatment of rosacea

Answer 17

metronidazole

Question 18

oral metronidazole has been shown to be a ___

Answer 18

carcinogen

Question 19

application of ___ gel by benzoyl peroxide may result in a temporary yellow discoloration of the skin and hair

Answer 19

dapsone

Question 20

chronic generalized mucocutaneous candidiasis is responsive to longterm therapy of ___

Answer 20

oral ketoconazole

Question 21

the antifungal activity derives from selective inhibition of squalene epoxidase, a key enzyme for the synthesis of ____

Answer 21

ergosterol

Question 22

an essetinal component of fungal cell membranes

Answer 22

ergosterol

Question 23

the powder or powder aerosol may be used chronically following initial treatment in patients susceptible to ___ infections

Answer 23

tinea

Question 24

nystatin and ampB are useful in the topical therapy of ___ but ineffective against dermatophyes

Answer 24

C. albicans

Question 25

most significant adverse effects of ___ include gynecomastia, elevation of hepatic enzymes and hepatitis

Answer 25

ketoconazole

Question 26

adminstration of the oral azoles with midazolam, triazolam, or HMG-CoA inhibitors are ____

Answer 26

contraindicated

the severe side effects

Question 27

reducing the particle size of the medication greatly___ absorption of the drug - griseofulvin - ultramicronized

Answer 27

increases

Question 28

most effective in treating tinea infection of the scalp and nonhairy skin

Answer 28

griseofulvin

Question 29

nonhairy skin is called

Answer 29

glabrous

Question 30

__ is derived from a PCN mold so cross sensitivity with PCN may occur

Answer 30

griseofulvin

Question 31

effective against oncyhomycosis if given oral

Answer 31

terbinafine